Cerebral Metabolism Following Traumatic Brain Injury

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2DG Autoradiography Showing an Increase in
Glucose Metabolism Following Fluid Percussion
Injury
FDG PET Showing an Increase In Glucose
Metabolism in Man Following TBI
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Dynamic Changes Following Human TBIA Triphasic
Pattern
Bergsneider et al., J Neurosurg 861997
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Normal
Mild GCS 15
Severe GCS 5
Concussion ?
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Cortical gray matter CMRglc is dissociated from
arousal state of patient
GCS at PET 15
GCS at PET 3-14
GCS at PET 3
Bergsneider et al., J Neurotrauma 172000
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Depression of glucose utilization appears to
occur primarily in the cortical gray matter
Normal control
TBI
Wu