Deployment Exposure Biomarkers Update

1
Deployment Exposure Biomarkers - Update

• Dr. Jack Heller
• Deployment Environmental Surveillance Program
• USACHPPM

2
Introduction

• USUHS/CDC/AFIP/CHPPM Study
• NMRC/CDC/VA/CDC Gulf War Marine Cohort Study
• Current Operations Kosovo

3
USUHS/CHPPM Study

• Blood and urine exposure biomarkers prospective
  study
• Test performance sensitivity, specificity and
  ability to detect change
• Determine cost effectiveness and applicability
  for risk assessment of chemical exposures
• Use in conjunction with environmental and
  personal (CBID) monitoring

4
USUHS/CHPPM Study

• Grant proposal submitted July 00 to MRMC
• Grant proposal to DHRP upcoming
• FY 01 - Field test site selection and preparation
• FY 02 - Field test and environmental sampling
• FY 03 - data analysis and evaluation

5
USUHS/CHPPM Study

• Study chemicals
• VOCs in blood
• Chemical weapons in urine
• Uranium is urine
• Comparative environmental samples
• Air/water/soil
• Personal sampler VOCs

6
NMRC/CHPPM Study

• Exposure Biomarkers in Serum Retrospective Gulf
  War Study
• Determine if cohort of US Marines in Persian Gulf
  was exposed to selected chemicals
• Evaluate bio-monitoring methods to develop simple
  and effective methods for exposure assessment
• Establish a limited database and serum repository
  for future analysis of adverse exposures

7
NMRC/CHPPM Study

• Grant proposal submitted July 00 to MRMC
• Grant proposal to DHRP upcoming
• FY 01 - 100 random pairs (pre post deployment)
  of serum sample analyzed
• FY 01 - Additional analyses based on first
  samples
• FY 02 Compare data with survey data, clinical
  data, hospitalization data and temporal
  geographic exposure data

8
NMRC/CHPPM Study

• Study chemicals
• Vanadium - oil fire exposure
• Chlorinated pesticides
• Nerve agents
• Sulfur mustard

9
Current Deployment Exposure

• Contaminant lead
• Contaminated media air and soil
• Levels high
• Evaluation method blood lead level
• Remedy - shorten tour

10
Current Deployment Exposure

• Field blood lead monitor
• Size - calculator
• Cost - 3000
• Analysis time 3 minutes
• Blood finger stick or venous puncture (50 ul)

11
Current Operations Exposure

• Cost/analysis 1.50
• Method printed circuit electrode
• Dilute with HCl and analyze
• Sensitivity ug/DL
• Demonstrated for - VP Secretary of HHS
• Used by CDC Russian, Peru and Egypt