HighEnergy Irradiation Facility for Biophysics Materials Research

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High-Energy Irradiation Facility for Biophysics
Materials Research
TAC-PAC meeting, GSI-Darmstadt, March 14, 2005
- Joint Technical Proposal -
Biophysics Collaboration Spokesperson M.
Durante Deputy J. Miller GSI Contact D. Schardt
Materials Research Collaboration Spokesperson
S. Klaumünzer Deputy M. Toulemonde GSI
Contact R. Neumann
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Contents

• Uniqueness of the project at the foreseen start
  of FAIR
• Technical approach
• Impact on FAIR design
• WPs, milestones
• Cost estimates

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1.Justification and uniqueness
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Research Goal
To enable a permanent human presence in space
with acceptable risks from radiation
Exploration of space is not possible until we
can inform astronauts on risks from radiation
Astronauts take space walks because they
understand the risks
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Role of Uncertainties in Risk Projections
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Maximum Acceptable Risk
Mars Mission
?
1
?
ISS Mission
SPE??
Lunar
0.1
?
95 Confidence Interval
Shuttle Mission
?
.01
Point Estimate
Individuals Fatal Risk
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Motivation for Particle / Energy range
Keywords Materials Science U 10 GeV/u
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Unique Damage to Cells by Heavy Ions-
NSRL-Brookhaven Results
Titanium 2 Gy
Gamma-rays 2 Gy
Primary human fibroblasts irradiated with 2 Gy
g-rays or Titanium ions at NSRL-1. Immunostained
for phosphorylated-H2AX a beacon for sites of
DNA double strand breaks (DSBs). DSBs are
clearly visible along the Ti ion tracks through
the cells.
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FAIR-BIOMAT a unique facility

• Rasterscan system
• Fast active energy modulation
• Combination with low-energy facility
  (UNILAC-SIS18)

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2. Technical approaches
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Technical Approach - Feasibility

• Rasterscan gt10 years experience with therapy
  beam
• Hardware existing scanner magnets from Cave M
  
• beamline components from Cave M / A
• Monitor chambers from Cave M / A
• Controls/Software Redesign / new development
  according to
• state-of-the-art technology
• Target Positioning
• Hardware Industrial standard components based
• on existing system in cave A
• Controls/Software Commercially available
  components,
• partially own development (LabView etc.)

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Beam Parameters I
Maximum intensity at 10 GeV/u
Bio 5.0E10 1.5E10 1.5E10 5.0E08 1.5E08
7.0E07 3.5E07 1.5E07 1.5E07
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Beam Parameters II

• Slow Extraction
• typ. 5sec for scanned beams
• flat extraction profile
• fast extraction interrupt
• Fast Extraction
• ns to ms pulse width
• only for selected experiments
• Beamtime scenario
• Typically short beam times (days)

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3. Impact on FAIR layout
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Impact on FAIR Layout
Request Particles p . U Energy 100
MeV/u 10 GeV/u Intensities 103108/sec

• Connection to SIS100 SIS18
• Cave shared with SPARC collaboration

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Preliminary Cave Layout
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4. WPs, milestones
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Working Packages Responsibilities

• BM1 Target Area (Development/Test/Installation)
  
• BM1.1 Target Positioning Devices (B.3) B M E
• BM1.2 Multi-purpose UHV chamber (B.5) M E
• BM1.3 High Pressure Cell (B.4) M E
• BM2 Civil Engineering BIOMAT
• BM2.1 Cave F
• BM2.2 Control Room (C.1) F B M
• BM2.3 Bio Labs (C.1) F B
• BM3 Electronics Software
• BM3.1 Machine Interface (C.2) B
• BM3.2 Control Software (C.2) B
• BM4 Beam Line Installation B M
• BM4.1 Beam Pipe Vacuum (B.1) B M
• BM4.2 Scanner Beam Shaping (B.2,B.3.1, B.3.2
  ) B
• BM5 Commissioning

Responsibilities Biophysics / Materials Science
/ External Groups / Fair Project Team
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• Experimental Halls / Cave A/M are essential for
  preparation to
• FAIR experiments. It would be highly desirable to
  reduce the time gap
• between the shutdown of those caves and the new
  facility to
• a minimum (lt1 year).

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5. Cost estimates
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Cost Estimate (priority list)
Civil Construction not included!

• Scanner Control/Software 745.000
• (Therapy project worst case, i.e. new
  develop.)
• Control Room 180.000
• (Best Guess)
• Target Handling 100.000
• (Best Guess)
• Lab space 300.000
• (4 rooms 2 clean, 1 animal, 1 chemistry)
• X-ray facility 150.000
• (Company information)

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Biophysics Collaboration
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Thank you very much!
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Comparison of Occupational Injuries -
differences in life shortening
Occupational 7.5
External Guidance- - Risks from radiation
should be less than other risks Astronauts
incur -3 in LEO based on ground based comparison