Gene expression

1
Gene expression
gene
active gene product
2
transcription
translation
processing
gene
polypeptide
mRNA
processing
transport
activation
active protein
3
Regulation of Gene expression
rate of transcription
RNA processing
stability of mRNA
rate of translation
(posttranslational modification)
(transport, activation)
stability of protein
CONCENTRATION OF ACTIVE PROTEIN
4
Patterns of Gene expression
constitutive - always expressed in all cell types
developmentally regulated
organ/tissue specific
environmentally regulated
metabolically regulated
hormonally regulated
RBCS
5
?-globin promoter