Neutrality Tests of DNA Sequences

1
Neutrality Tests of DNA Sequences We are
generally interested in using DNA sequence
surveys of polymorphism and divergence to study
how mutation,selection and drift act on specific
genes. Most of our work has focused on
mtDNA where data reveal an excess of amino acid
polymorphism, suggesting the deleterious
mutations Govern mtDNA evolution. Our recent
studies have focused on regions of very low
recombination at the tip of The X and 4th
chromosome in Drosophila. These data show an
mtDNA-like pattern of excess amino
acid polymorphism at the tip of the X, and show
how recombination and dominance modulate
selection on amino acid variation
Weinreich, D. M. and D. M. Rand, 2000
Contrasting patterns of non-neutral evolution in
proteins encoded in nuclear and mitochondrial
genomes. Genetics 2000 156 385-399. Sheldahl, L.
S., D. M. Weinreich, and D. M. Rand. 2003.
Recombination, dominance and selection on amino
acid polymorphisms in the Drosophila genome.
Submitted to Genetics 12/02