Bud Mishra

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Bud Mishra

• Asking big questions

Human Genome Technologies Who are we (humans)?
Sequencing genomes quickly, cheaply and
accurately (haplotypically) Measuring gene
expressions accurately. Human Population
Genomics Where did we come from? Why arent we
extinct? Polymorphisms Migration Patterns
Selection of traits Diseases Why do we suffer?
Genetic basis of diseases Therapeutic
interventions Predictive and Individualized
medicine For cancer, neurodegeneration, chronic
fatigue immune deficiency syndromes, autism,
schizophrenia, etc.? Immortality Why do we die?
Biochemical pathways involved in longevity and
diseases
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• Answering big questions needs ideas from computer
  science
• Human Genome Technologies Developing bio- and
  nano-technologies Single molecule analysis via
  optical and AFM imaging and mage processing.
  Algorithm design Taming intractability by
  optimal experiment designs (thus exploiting
  probabilistic analysis and 0-1 Laws) Bayesian
  analysis and efficient statistical algorithms
• Human Population Genomics Modeling polymorphisms
  (single nucleotide and copy number
  polymorphisms) Statistical/Machine-learning
  techniques to determine population structure and
  stratification Non-parametric models of
  underlying stochastic processes (a nontrivial
  generalization of graphical models) Detecting
  positive selection Disease association studies
• Diseases Systems biology approaches to
  understand disease progression Computational
  models of somatic evolution in cancer model
  checking using hidden Kripke Models Causal
  analysis using PCTL and empirical Bayes false
  discovery control
• Immortality Get involved before it is too late!!
  Achieve it, not through your research, but by not
  dying!!