Hepatobiliary Physiology

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Hepatobiliary Physiology

• Jim Pierce
• Bi 145b
• Lecture 9, 2008-9

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Hepatobiliary Physiology

• Lets talk a little bit aboutthe Liver and the
  Pancreas
• Why do the get lumped together?

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Hepatobiliary Development

• Liver and Pancreas originate
• as diverticula from the FOREGUT
• Liver develops Ventral
• Pancreas head develops Ventral
• Pancreas body tail are Dorsal

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Hepatobiliary Development
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Hepatobiliary Development
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Hepatobiliary Development
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Hepatobiliary Development
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Hepatobiliary Anatomy
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Hepatic Anatomy
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Sub Hepatic Space
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Hepatic Anatomy
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Hepatic Anatomy
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HepaticCirculation
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Hepatic Circulation
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Hepatic Circulation

• 20 of Cardiac Output goes to the liver
• Blood comes from Both
• Two Thirds from the Portal Vein
• One Third from the Hepatic Artery
• Oxygen comes from Both
• Half from the Portal Vein
• Half from the Hepatic Artery

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Hepatic Tubes
Blood enters via The hepatic artery The portal
vein Blood leaves via The hepatic vein But
there is one more tube The bile duct
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Portal Triad
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Hepatic Circulation

• The portal system is a train between the gut and
  the liver
• Blood enters via the portal triad
• Bile exits via the portal triad

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Portal Triad
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Hepatic Lobule
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Hepatic Lobule
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Hepatic Lobule
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Hepatic Vein
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Hepatic Circulation

• Blood enters via the portal triad
• Blood is distributed to lobules
• Blood exits via the hepatic veins
• Bile exits via the portal triad

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Gallbladder

• Bile doesnt godirectly to the gut
• Bile collects in the Gallbladder
• Here, bile becomesmore concentrated
• Bile is then excretedwhen it is needed

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Gallbladder Histology
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Hepatobiliary Anatomy

• To understand how the bile gets tothe gut, we
  need to remember hepatobiliary development

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Hepatobiliary Anatomy
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Hepatobiliary Drainage
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Pancreas Head
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Lesser Sac / Pancreas
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Pancreatic Ducts
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Hepatic Anatomy
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Liver Function
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Liver Function

• Blood Extracellular Matrix
• Detoxification and Blood Filtration
• Reservoir
• Reticuloendothelial System
• Amino Acids, Lipids, Carbohydrates
• Energy
• Regulation of Blood Glucose
• Production of Backup Carbon Energy Sources
• Bile Production

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Bile

• Bile is composed of
• Bile Acids
• Cholesterol
• Lecithin
• Of course, there is also NaCl and H2O

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Bile Secretion
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Bile Secretion
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Gallbladder Function

• Bile is produced continuously
• It is collected in the Gallbladder
• It is secreted in response to
• Cholecystokinin (CCK)
• It is then introduced to the Duodenum

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Enterohepatic Circulation
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Enterohepatic Circulation

• This circulation facilitates
• Excretion of lipophilic waste
• Absorption of lipophilic nutrients
• Mixing of chyme

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Pancreatic Secretion
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Pancreatic Secretion
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Pancreatic Secretion
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Control of Pancreatic Secretion
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Hepatobiliary Secretion

• The Duodenum
• Receives Chyme from the Stomach
• Receives Juice from the Liver Pancreas
• Begins Digestion and Absorption

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Questions?