InsulinLike Growth Factor 1

1
Insulin-Like Growth Factor 1

• Fatemeh, Lara, Ryan, and Kevin
• Biology 349
• Spring 2007

2
The Question

• While studying cell signaling, your lab partner
  Pete
• thinks he has stumbled upon the secret to the
• fountain of youth, an intercellular message
  called
• insulin-like growth factor (IGF-1). Help Pete
• figure out how the message works, whether IGF-1
• might be used to prolong life, and if there
• could be any side effects.

3
What Pete Heard about IGF-1

• Promotes cell survival
• Boosts Metabolism
• Improves energy and endurance
• Promotes growth of new muscle cells
• Restores and maintains bone and muscle mass
• Promotes healthy joints
• Boosts Immune System
• Supports sexual performance

4
Supported Evidence of IGF-1

• Production
• 80 of IGF-1 is produced in the liver (endocrine)
• 20 is produced in other tissues (paracrine)
• Effects
• Growth of bone, cartilage, and other tissues
• Promotes protein synthesis
• Increases hepatic glucose output.

5
How Does IGF-1 Work?
Tyrosine Kinase

• IGF-1 (Insulin Agonist) ?
• IGF /Insulin Receptor ?
• Phosphorylation of PI3K ?
• Stimulates AKT pathway to prevent apoptosis and
  promotes cell survival in a variety of tissues.

6
Side Effects

• Increase risk of cancer
• Increase cell life Decrease life span
• Shortening of telomeres and aging
• Studies
• Mice and calories
• Worms and IGF-1
• Children and IGF-1 (Tercica)
• DONT DO IT PETE!

Breast Cancer Cell
Prostate Cancer Cell
7
IGF-1 Analogy
Picturehttp//wesclark.com/am/mouse_trap.jpg
8
References

• http//sustain.no/virtue/newsletter/00_12/sci-gote
  borg/thrandur/index.php
• http//www.acromegalyinfo.com/info/understanding/a
  cromegaly-causes.jsp?usertrack.filter_appliedtrue
  NovaId3350119488824112919
• http//www.biocarta.com/pathfiles/m_igf1rPathway.a
  sp
• http//www.chemlin.net/news/2006/sep2006/therapeut
  ic-molecules.htm
• http//www.mayoreferenceservices.org/media-comm/mc
  2831-0306.pdf
• http//diabetes.diabetesjournals.org/cgi/content/f
  ull/50/2/255
• http//www.stanford.edu/group/brunet/research20in
  terests.html
• http//arbl.cvmbs.colostate.edu/hbooks/pathphys/en
  docrine/otherendo/igfs.html
• http//www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id
  147440
• http//trca.client.shareholder.com/ReleaseDetail.c
  fm?ReleaseID171776
• Silverthorn, Dee U. Human Physiology.
  Pearson/Benjamin Cummings. 2007.