Polymers in Medicine

1
Polymers in Medicine

• Dr. Clower

2
Polymers

• Natural vs. synthetic
• Industries
• What is a polymer?
• Monomer
• Dimer
• Oligomer
• Polymer

3
Structure

• Linear
• Branched
• Crosslinked
• Dendrimers

4
Properties

• Size and structure
• Density
• Crystallinity
• Strength
• Example

5
Naming

• Simple polymers

6
Copolymers

• Alternating
• Block
• Graft
• Random

7
Nylons

• Hexanedioic acid (adipic acid)
  1,6-hexanediamine (hexamethylenediamine)
• Nylon 6,6
• Nylon 6

8
Kevlar
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Polyesters

• Poly (ethylene terephthalate)

10
Polyurethanes

• Spandex
• Other polyurethanes

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Polycarbonates

• Lexan

12
Other polymers of note

• PTFE
• 1,1-DCE
• PMMA
• PEA
• Cyanoacrylates
• PP

13
Polymerizations

• Step-growth/condensation

14
Polymerizations

• Chain/addition

15
Polymers in medicine

• Choosing a polymer
• Design
• Biodegradability
• Other factors

16
Biodegradable polymers

• Degradation
• Sutures
• Polyglycolide (PGA)
• Polylactide (PLA)
• Copolymers

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Other medicinal uses

• LDPE
• PP
• PTFE
• PMMA
• Poly(2-hydroxyethyl methacrylate)

18
Other medicinal uses

• Polyamides/Nylons
• PETE
• PLA/PGA
• Poly(dimethylsiloxane)
• Poly(ether urethanes)
• PVC

19
Drug delivery

• Drug-polymer conjugate
• http//www.neurospine.com/brain_gliadel.htm
• http//www.moffitt.usf.edu/pubs/ccj/v5n2/article4.
  html

Drug
linker
polymer