Sustainable Medicine New Directions for Research

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Sustainable MedicineNew Directions for Research
David Servan-Schreiber, MD, Ph.DClinical
Professor of Psychiatry, University of
Pittsburgh Lecturer, Faculté de Médecine Lyon
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Current Model
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The Tibetan Principle

• Myocardial infarction, Pneumonia, Appendicitis
• CAD, Cancer, Diabetes, Depression, Arthritis...

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Coronary Artery Disease

• Ornish, 1995 JAMA
• Treatment as usual
• Vegetarian diet exercise meditation group
  support

Baseline
5 years later
Control
Program
Myocardial Perfusion 13 N PET Scan
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A Story

• Pittsburgh, late1992

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Epidemic 1 -Evolution
SEER, 2003 NCI
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Epidemic 2 - Distribution
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Key difference Lifestyle
For 100,000
Sasco, 1989 Rev Med Int
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Prevention AND Treatment

• Lifestyle factors can cause or protect from
  cancer
• Can they affect treatment too?

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Behavioral Changes and Breast Cancer
Intervention
Control
68 reduction in mortality
Andersen et al., 2008 Cancer
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Nutrition
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Mediterranean Diet
Eposito et al, 2004 JAMA
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Omega-3 / Omega-6
Feller et al., Jal. Am. Chem. Soc.., 2002
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Duckett et al., 1993 J Animal Sci
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Transformation of food chain
x20
Omg-6 /Omg-3
x15
x10
x6
Ailhaud et al., Prog. Lip. Res., 2006
Simopoulos Salem. NEJM, 1989
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Evolution of Diet
WW II
Calories
Saturated Fat
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Omega-6 Fatty Acids
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Omega-3 Fatty Acids
- 4M
- 10,000
1800
1900
2000
Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987
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Omega-6 fatty acids and mammary tumors
Nb of tumors
Days post graft
Carroll et al, 1975 Cancer Res.
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Advanced Breast Cancer
Gago-Dominguez et al., 2003 Brit J Ca Singapore
Prospective 35 298 women
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Membrane Protection
Neuronesexposed to beta-amyloid
Neuroneswithout anything
Neuroneswith omg3 exposed to beta-amyloid
Neuroneswith omg3
Florent et al. Jal. Neurochem., 2006
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Prevention Framingham Study
RR0.53
Schaefer et al, 2006 Arch Neurol.
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Treatment Omega-3 AD Study
Omega-3
Placebo
Freund-Levi et al, 2006 Arch Neurol.
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Statins or Omega-3s?
Cardiac Mortality
-22
-32
Studer et al, Arch Int. Med. 2005
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Statins or Omega-3s?
All Cause Mortality
-13
-23
Studer et al, Arch Int. Med. 2005
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Flaxseed Project

• 5 flax seed in animal feed ?
• Meat, butter, eggs, cheese, milk balanced in
  omega-3s ?
• Impact on human biological parameters
• (INRA, CHU Rennes, CHU Lorient)

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Childhood Cancers - Europe
Steliarova-Foucher et al., 2005 Lancet
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Organic vs Conventional Food

• 42 children 2 to 5 yo - Seattle, Wash
•  organic  children below EPA safety limit
•  conventional  children 4 x above

Curl et al., 2003 Env. Health. Persp.
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Summary

• Many scientifically sound complementary and
  environmental approaches
• Which is the best medicine? Which is more
  scientific?
• No patent no profits no awareness

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• Sent Thur. 02/28/08 540 pm
• To XXX
• Great. Thanks. G is a great guy, say hi, and I
  will keep looking out for the good science he
  does. Even so, the chances of commercial success
  hinge on the patent life of a molecule, and we
  have our hands full with stuff that has that sort
  of potential.
• Best,
• XXX
• Clinical Director, XXX

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New Research Orientations

• 1. Natural/sustainable treatments
• 2. Intellectual property protection
• 3. Environmental interventions

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The End