Diapositive 1

1
Cyclin-Dependent Kinases (CDKs)
Cyclin A
CDK1
Cyclin B1-3
CDK2
Cyclin C
CDK3
Cyclin D1-3
Cyclin E
CDK4
Cyclin F
CDK5
Cyclin G
CDK6
Cyclin H
CDK7
Cyclin I
Cyclin K
CDK8
Cyclin T
CDK9
Homo sapiens 30,000 genes 518 kinases 13 CDKs 25
cyclins
p35/p39
CDK10
Cyclin L
CDK11
Cyclin L
2
Cyclin-Dependent Kinases (CDKs)
Cell cycle regulation
CDK4
CDK1
CDK6
CDK7
CDK2
CDK3
Apoptosis
CDK1
CDK2
CDK5
Transcription
CDK7
CDK8
CDK9
Neuronal functions
CDK5
CDK10
CDK11
3
CDC25B
CDC25A
p21 CIP1
CDC25B
CDC25C
p27 KIP1
G2
p57 KIP2
S
M
CDC25A
G1
p16 INK4A
p15 INK4B
p18 INK4C
p19 INK4D
CDC25B
4
Glycogen synthase kinase -3 (GSK-3)
GSK-3a
Cell cycle regulation Apoptosis Wnt signaling
Insulin action Transcription DNA damage
response Development Neuronal functions
GSK-3b2
( 13 aa)
5
Glycogen synthase kinase -3 (GSK-3)
Ser-9
Tyr-216
T-loop activation site
GSK-3
Auto-inhibitory P-Ser
ATP
S
S
Nt
Ct
Docking protein
Substrate
ATP
Priming P-Ser
Priming kinase
6
Alzheimers disease
Presenilin 1/2
Senile Neuritic Plaques
?-APP
P
Neurofibrillary Tangles (Paired Helical Filaments)
TAU
7
Alzheimers disease
Alzheimers disease
T354
Senile Neuritic Plaques
?-APP
T668
P
Neurofibrillary Tangles (Paired Helical Filaments)
TAU
8
Alzheimers disease
Alzheimers disease
?
Senile Neuritic Plaques
?-APP
?
?
?
?



P
Neurofibrillary Tangles (Paired Helical Filaments)
TAU
?
CDC25
9
Alzheimers disease
Alois Alzheimer