CHE5480 Summer 2005

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CHE5480 Summer 2005

• Dendrimers
• June 14, 2005

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Starburst Dendrimers
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What is a dendrimer? Branched polymers
(dendron tree in Greek)Functionality 3
(Nitrogen)
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Silicon, Si, functionalty f4
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Rose bengal inside PPI dendrimer.
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Dendrimers

• 1. Manufacture
• 2. Structure
• 3. Characterization
• 4. Applications

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Manufacture

• (i) Divergent Method
• (ii) Convergent Method

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Methods of Synthesis(i) Divergent Growth
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Methods of Synthesis(ii) Convergent Growth
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Comparison Divergent vs. Convergent
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Structure
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Generations of Dendrimers
Your Text Here
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Generations of Dendrimers
2nd gen.
5th gen.
4th gen.
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PAMAM Dendrimer (polyamidoamine)

• Alternating
• (B)-AB-AB-AB-...
• Ethylenediamine (B)
• H2N-C-C-NH2
• Methylacrylate (A)
• CC-CO-OCH3

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PAMAM Moieties
Diamine
Acrylate
NH3 or Diamine
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Characterization
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f3
fc3
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2
3
generations
Spacer b
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Construction of Generations

• Core Ethylenediamine (Moiety B D)
• Michael Addition of 4 Methylacrylates (A O)
• Amidization add 4 ethyldiamines (D)
• Result Generation 0

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Continue Branching
Generation 1
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Generation 2
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Calculations

• Note that
• Core functionality (2 nitrogens) fc 4
• Branch functionality (nitrogen) f3
• No. of Spacers (AB) b2
• Generation G

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Number of Branches Nbr
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Number of Mers (AB) Nmer
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Applications of Dendrimers

• Gas and chemical sensors
• Catalysts
• Drug delivery and gene therapy
• Surface modifiers (tribology, and information
  storage)
• Bio compatible materials
• Electronic devices and antennae

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Size of PAMAM DendrimersGeneration
M.W. Angstrom (dia.)
End Gps
(1 nm 10 Angstroms)
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Equivalent Sizes with Cells
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Dendrimer PAMAM
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2. Nanostructured materials Gas adsorption in
dendrimers