from Malaria Institute at Macha

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from Malaria Institute at Macha
Report to Malaria Research Working Group

• Phil Thuma, M.D.
• Executive Director
• Sungano Mharakurwa, Ph.D.
• Scientific Director

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Projects On-Going at MIAM

• I. Epidemiology
• Pilot study focusing on community gametocyte
  carriage
• using GIS mapping
• community parasite prevalence studies
• community anaemia studies
• longitudinal and cross-sectional components
• questionnaires for epidemiological variables

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Projects On-Going at MIAM

• I. Epidemiology contd.
• Hospital chart review to determine patterns of
  malaria burden over time
• changes in malaria case load after introduction
  of ACT
• changes in need for paediatric blood
  transfusions after introduction of ACT
• changes in malaria severity pattern and
  childhood mortality after introduction of RBM

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Projects On-Going at MIAM

• II. Entomology
• Insectary with colony of anophelines
• Community mosquito collections to determine
  carriage of P falciparum
• Sampling for over-wintering of anophelines
• PCR methods to differentiate anopheline species

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Projects On-Going at MIAM

• III. Molecular Biology
• Parasite drug resistance fitness studies
  molecular changes in relation to drug pressure
  and vector control
• Development of malaria diagnostics using urine or
  saliva samples instead of blood
• - PCR
• - RDT
• - LAMP (in preparation)

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Projects Planned at MIAM

• Clinical Studies
• Pharmacokinetics of sulphadoxine/pyrimethamine
  (SP) in pregnancy

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Macha Mission Hospital

• 208 bed rural, district-level hospital
• Serves approximately 160,000 people in three
  districts
• On-going malaria research programme since 1988
• Prospective data collection
• Stable paediatric medical staff for 20 years
• Quality clinical and research lab facilities

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Macha Hospital Under 5 hospitalized malaria
cases
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SP Interim Policy
A/L in Kalomo District
A/L in Choma District
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RHCs U5 Malaria Cases
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Macha Hospital Pediatric Malaria Cases vs
Rainfall
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Macha Hospital Pediatric Malaria Cases vs
Rainfall
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Macha Hospital Pediatric Malaria Cases vs
Rainfall
1418
423
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1,479
1,778
1,294
1,418
423
123
552
290
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Macha Hospital - Monthly Pediatric Blood
Transfusions
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