CMI

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Innate immunity
CMI
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Exogenous antigen
ClassII HMC-immunogenic peptide
Proliferation
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Mediators (secretory substances) from any cells
Cytokines
Lymhocytes
Lymphokines
Monocytes
Monokines
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CD4
APC
Lymphokines
Monocytes/Macrophages
Polymorphonuclear cells
T lymphocytes
B lymphocytes
etc..
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Effect of lymphokines on Monocytes/Macrophages
CD4
APC
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MCF
APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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Effect of lymphokines on polymorphonuclear cells
APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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APC
CD4
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CD4
APC
Lymphokines
Monocytes/Macrophages
Polymorphonuclear cells
T lymphocytes
B lymphocytes
etc..
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Effect of lymphokines on T Lymphocytes
Lympho -kines
Interleukin-2 IL-2
Mitogenic factor Blastogenic factor
Autocrine
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Effect of lymphokines on B Lymphocytes
T and B cell co-operation
Thymus independent antigen (T independent
antigen)
Thymus dependent antigen (T dependent antigen)
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Thymus dependent antigen
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Factor Affecting Hematopoiesis
Stem cells in Bone marrow
APC
CD4
Increase WBC in circulation
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Lymphokines
Exogenous Ag
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Overall Action of cytokines
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Innate immunity
CMI
Phagocytes
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Nomenclature of cytokines
Cells
Cytokines
Various biological functions
Nomenclature
Interleukin (IL)
IL1, IL2, IL3, IL4IL22
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APC
classII MHC
Lymphokines
Interleukins
CD4 T cell
Various biological activities
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Sub-populations of CD4 T lymphocytes
Th1 cell
Th2 cell
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IL2
IL5
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Immune response to virus infection and tumor
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CD8 lymphocytes
Destroy
Virus infected cells
Tumor cells
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Virus infected cells
Tumor cells
Endogenous antigen
Virus infected cell
Tumor cell
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Virus infected cells
Tumor cells
Endogenous antigen
Tumor cell
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CD8 lymphocytes
(Cytotoxic T cells)
Recognize cells which express endogenous antigen
Virus infected cells
Tumor cells
Cell lysis
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Virus
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Transporter associated with antigen processing
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CD8 cells activation
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Accessory molecules
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Lysis of Virus infected cells Tumor cells
Cytotoxin , Pore-forming proteins
CTL response
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CTL
CTL
CTL
Target cell
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Innate immunity
HMI
CMI
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CD4 T cell
CD8 T cell
Target cells or APC
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Invariant chain(Ii)