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An-Najah National UniversityChemical
Engineering Department
Microemulsion In Drug Delivery Systems
Prepared by
Ibtihaj Awwad
Alaa Badran
Hanaa Tareq
Hadeel Suliman
Superior Dr. Husni Odeh Submitted to Chemical
Engineering Department
Second Semester, 2010-2011
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Outline

• Objectives.
• Microemulsion .
• Advantage and disadvantage of microemulsion.
• Solubility and Bioavailability.
• Earlier study of microemulsion in the drug.
• Materials.
• Experimental work.
• Results and discussion.
• Conclusion.
• Recommendation.

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• The objectives
• This project aim to design and develop of
  microemulsion drug delivery system .
• Improved the solubility and bioavailability of
  curcumin drug by using microemulsion.

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Microemulsions

• Microemulsion are liquid dispersions of water
  and oil that are made homogenous, transparent and
  thermodynamically stable by the addition of
  relatively large amounts of surfactant and
  co-surfactant and having diameter of the droplets
  in the range of 100 1000 A (10 100 nm).

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The advantages of Microemulsion

• Microemulsions are thermodynamically stable
  system and the stability allows
  self-emulsification of the system whose
  properties are not dependent on the process
  followed.
• Microemulsion have low viscosity compared to
  other emulsions.

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• Microemulsion can improve the efficacy of a drug,
  allowing the total dose to be reduced and thus
  minimizing side effects.
• microemulsion are easy to prepare and require no
  significant energy contribution during
  preparation. 

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The disadvantage of Microemsultion

• Use of a large concentration of surfactant and
  co-surfactant necessary for stabilizing the
  nano-droplets.
• The surfactant must be nontoxic for using
  pharmaceutical applications .

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• Microemulsion stability is influenced by
  environmental parameters such as temperature and
  pH.  These parameters change upon microemulsion
  delivery to patients.

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BIOAVALABILITY

• Bioavailability of a drug is largely determined
  by the properties of the dosage form.
• The therapeutic index ratio of the minimum
  toxic concentration to the median effective
  concentration.
• Low bioavailability is most common with oral
• dosage forms of poorly water-soluble, slowly
  absorbed drugs.

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SOLUBILITY

• Solubility the amount of a substance that
  dissolves in a given volume of solvent at a
  specified temperature.
• Poor aqueous solubility .
• High lipophilicity.

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Earlier Studies On Microemulsion In The drug
Bioavailability increases (12.78 times)
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The release increased more than 90 when compared
with marketed formulation
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• Material
• The drug curcmin (anticancer).
• The surfactant and co-surfactant Tween20
  (Polysorbate), Spans80(Sorbitan monooleate)
• Oil Jojoba with clove (95/5) and clove
  oil(100)

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The Procedures
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Microemulsion Formulation
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Table(1) Initial concentration values of oil and
Sur. Mix. For the two systems
Amount of oil 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8
Amount of Sur. Mix 1.8 1.6 1.4 1.2 1 0.8 0.6 0.4 0.2
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• Drug solubility experiments
• Drug solubility experiments were carried out
  based on the previous microemulsion experiments.
  It was experienced that for
• First system jojoba oil and clove oil
• surfactant/co-surfactant, oil, water(3.01,27.07,
  69.9).
• surfactant/co-surfactant, oil, water
  (6,24.28,69.72).
• surfactant/co-surfactant, oil, water(9.02,21.11,
  69.87) .

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• Second system clove oil
• surfactant/cosurfactant,oil, water (3, 27.14,
  69,86).
• surfactant/cosurfactant,oil, water(6.02,24.06,69
  .92).
• surfactant/cosurfactant,oil, water
  (9.01,21.15,69.84) .

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Results and Discussion

• Due to the addition of water the shape and color
  of emulsions were changed.(3, 2, 1 phases)

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Results and discussion
Figure(1) Triangle Phase Diagram of oil , Sur.
Mix. And Water
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• The highest solubility of curcumin 5mg/ml is
  found at (20,10,70) (S mix./oil/water)
  microemulsion system.

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Conclusion

• Microemulsion is excellent candidate as potential
  drug delivery system.
• The microemulsion system occurred at (20 Smix
  ,10 oil ,70 water).
• The highest drug solubility of curcumine 5mg/ml
  is found at (20/10/70) (Smix/oil/water)
  microemulsion system.

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Recommendations

• 1. Microemulsion method is one of the best method
  of drug delivery to increase bioavailability of
  drug.
• 2. Deep study must be done for each material used
  in preparation
• of ME.
• 3. Careful dealing with components while adding
  them to the system.

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• 4. Use pre-calibrated devices for measuring
  amounts of
• components.
• 5. Use suitable shaking device that offer gentle
  mixing for several tubes that save time and
  effort.
• 6. Use Pure Water in Preparation of ME

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Thank You