STAT3???CD4 T???????????????

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STAT3???CD4 T???????????????
????(??)Yanwei Shen, Weiyi Peng, Yoshihiro
Miyahara, Shu Zheng, Rong-Fu Wang, and Helen Y.
Wang ????????????? ???????????????
330102198110071215 ????????,???
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• STAT????????????????????????????????,?????????????
  ???????????,???????????????
• ??STAT3??????????????????,??????????????????,????
  ??????? ????????,??STAT3????????????????,?????????
  ????????????

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• ?????,???? LoxP-Cre ??????CD4 T????????STAT3?????
  ????????????????????,???????CD4
  T????????,??TCR????????????????
• ?????????,??B16?????CD4-STAT3 ??????,???????????T?
  ?????????,?? STAT3 ???CD4 T??????CD8
  T??,???????B16?????
• ???????,STAT3 ???CD4 T???TCR???,???????CD4
  T??,??Bcl-2??,Bak ??? ??????STAT3????TCR????T?????
  ???,????T??????,??????T????????????

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• ?? STAT3-/- CD4 T ????
• CD4 T???????????????
• CD4 T?????????????
• B16????????T????????
• STAT3?????????

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• 1. CD4 T ??STAT3 ???????

Fig1. Loxp-Cre??????western blot ??CD4 T
???STAT3??
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• 2. STAT3-/- CD4 T ????
• Fig2. STAT3-/-???CD4?CD8 T??????
  STAT3f/f?????????

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• 3. STAT3-/-?????STAT3f/f??????CD4 T
  ?????????????
• Fig3A. nTreg???Th17???????,??Treg???????

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• Fig3B. ELISA????STAT3-/-? STAT3f/f ???CD4 T
  ???TCR?????????????

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• Fig4. STAT3-/-?CD4 T ???TCR????????????

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• Fig5. B16????????T????????,??STAT3-/-?CD4 T
  ????????????

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• Fig6A. STAT3???TCR????????

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• Fig6B. STAT3????????MAPK??????

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• ????STAT3-/-???CD4 T ????????????????????
• ??????????????????????????????????
• ????????T??????????,STAT3 ???CD4 T ?????????????
• STAT3-/-???CD4 T ????????????TCR???TCR??Bcl-2????
  ???MAPK????????
• ????????,STAT3???TCR???T?????????????,????????T???
  ??????????????