HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE, AND DEVELOP TREATMENTS FOR ALZHEIMER'S DISEASE? Part C

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HOW CAN NEUROIMAGING HELP UNDERSTAND, DIAGNOSE,
AND DEVELOP TREATMENTS FOR ALZHEIMER'S
DISEASE?Part C AD brain scans - anatomical

• NUCLEAR MEDICINE GRAND ROUNDS
• Stanford University
• J. Wesson Ashford, M.D., Ph.D.
• Clinical Professor (affiliated), Department of
  Psychiatry and Behavioral Sciences
• Senior Research Scientist, Stanford / VA Aging
  Clinical Research
• Stanford University and VA Palo Alto Health Care
  System
• January 5, 2010
• Slides at www.medafile.com (Dr. Ashfords
  lectures)

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BRAIN SCANNING TECHNIQUES

• ANATOMICAL BRAIN IMAGING
• CT cerebral tomography
• MRI magnetic resonance imaging
• FUNCTIONAL BRAIN IMAGING
• SPECT single photon emission computed
  tomography
• PET FDG Positron emission tomography
• BRAIN CHEMISTRY MEASUREMENT
• MRS (spectroscopy NAA/Cr estimate neuronal
  volume)
• BRAIN PATHOLOGY IMAGING
• PIB amyloid (many compounds under development)
• FDDNP neurofibrillary pathology

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Evolution of Neuroimaging in AD
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• Computed Tomography
• MRI
• Volumetric MRI
• Co-registration of MRI
• Functional MRI
• FDG Glucose PET
• Amyloid Imaging
• P-Tau imaging

FDG Glucose PET
Helmuth L. Science. 20022971260-1262.
Alzheimer Disease Forum. http//www.alzforum.org/n
ew/detail.asp?id948.
Lab of Neuro Imaging UCLA School of Medicine.
www.loni.ucla.edu/thompson/AD_4D/dynamic.html.
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NORMAL
ALZHEIMER
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Hippocampus outline
Entorhinal Cortex outline
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Braak and Braak stage vs normalized bilateral
hippocampal formation (HF) volume in subjects
with isolated AD pathology. Jack et al., 2002
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Jack et al., 1992
HF/TIV Hippocampal Formation / Total
Intracranial Volume
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AD-Designed Probability AtlasProbabilistic
Atlas of Hippocampal Volumes
Mega et al. 2002 UCLA Medical Center
Future MRIs will include estimates of disease
probability based on volumes. Volumes already
being done in some medical centers.