Absorption, Distribution, Metabolism and Elimination: Part I

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Absorption, Distribution, Metabolism and
EliminationPart I

• Joseph Graziano, Ph.D.

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Major Routes of Drug Administration

• Route of Administration
• Intramuscular
• Intravenous

• Absorption Pattern
• Prompt from aqueous solutions, but slow and
  sustained from repository forms
• Immediate effects,
• since absorption is
• circumvented

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Major Routes of Drug Administration

• Route of Administration
• Oral Ingestion
• Subcutaneous

• Absorption Pattern
• Variable depends on many factors
• Prompt from aqueous solutions, but slow and
  sustained from repository forms

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Other Routes of Administration

• Transdermal patch
• Inhalation
• Intra-arterial
• Intrathecal
• Topical ocular, dermal, intranasal,
  intravaginal routes all lead to some systemic
  absorption

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