NANO AND MICROTECNOLOGIES OF HYBRID BIOELECTRONIC SYSTEMS

1
NANO AND MICROTECNOLOGIES OF HYBRID BIOELECTRONIC
SYSTEMS 

• 0455-3045-01
• Ehud Gazit, Green 221, ehudg_at_post.tau.ac.il

2
Topics to be covered during the course

• Introduction of nanotechnology and
  bionanotechnology (Gazit)
• Self-Assembly and protein building blocks (Gazit)
• Metallization of proteins (Freeman)
• The interface between microelectronic and biology
  (Shacham)
• The use of cells in nano-scale networks (Hanein)
• Nano-medicine and drug delivery (Korenstein)
• Nano-electronics and relation to
  nanobiotechnology (Richter)
• Summary and prospective (Gazit)

3
Requirements of the course

• Compulsory attendance
• Seminar work
• - On one of the subjects discussed in course
• - The subject and literature should be
  approved by one of the
• course teachers by the end of the semester
  break
• - Should include both literature description
  as well as analysis
• of the work
• - To be submitted end 30th April, 2006

4
Bringing NANOtechnologies TO LIFENetwork of
Excellence Priority 3 - NMP
5
24 partners clustered at regional level
British Islands (21?)
Oeresund (1)
Bio-Analytik Muenster Twente (5)
NanoBioNet Saarbruecken (5)
NAS associated cluster (4)
Swiss cluster (2)
NanoBio Grenoble (3)
JRC Ispra (1)
PCB Barcelona (1)
Greek cluster (2)
Israël univ. (1)
6
Core partners Nano2Life Network
7
(No Transcript)
8
List of industrial collaboration (I)

• Semiconductors Industry
• Intel - World Largest Electronic Chip
  Manufacturer
• Tower Semiconductors
• Jordan Valley
• Applied Radiation - Metrology
• CI technologies - Metrology
• Applied Materials - Metrology
• KLA-TENCOR - Metrology
• Nova measurement technologies - Metrology
• Semiconductor Devices Ltd. - detectors
• Nanolab - Micro Mechanics
• Tevet - Metrology
• Nanopass Micro Mechanics
• Texas Instruments - Electronic Chip Manufacturer

• Defense Industry
• IAI (TAMAM)
• SCD (HAMAM)
• El-Op Optical systems
• Communication Industry
• Colourchip - optical communication
• Lenslet - optical communication
• Galay-Or - optical communication
• SivCom optical communication
• Tera-Op - optical communication
• PhoneOr - optical communication

9
List of industrial collaboration (II)

• Pharmaceutical Industry
• American Home products-Major Pharmaceutical
  House
• TEVA- Major Generic Pharmaceutical House,
• Johnson Johnson- Major Pharmaceutical House
• QBI - Small size Data Mining Firm, collaboration
  with Major Pharmaceutical Houses
• Glycominds - Pharmaceutical Start-Up
• Peptor- Pharmaceutical Start-UP
• Taro Pharmaceuticals - Medium size Generic
  Pharmaceutical House
• D-Pharm - Pharmaceutical Start-UP
• Bayer - World Leading Pharmaceutical and Chemical
  Manufacturer

10
Multi disciplinary researchat Tel-Aviv University
11
Highlights Equipment

• Nano-LithographyE-Beam Raith 150
  Jeol 6400 Elphy
• Imaging FEG-TEM Philips HRSEM Jeol 6700
• Analysis SQUID (Superconducting Quantum
  Interference Devices)
• TOF-SIMS
• AES
• XPS

12
What is nanotechnology?

• The name stems from the Greek root nanos ???
• Material small that gt1 micron or few hundreds nm
• The properties of matter are changed as a
  function of size
• One-dimensional and two-dimensional materials
• Large emphasis on self-assembly
• properties complex systems from
• simple building blocks

13
Suggested applications
14
The building blocks of nanotechnology

• Atoms (as Xenon atoms on Copper)
• Molecules (functional, smart, structure)
• Clusters (such quantum dots)
• Non-covalent assemblies (self-assembly
• and patterned structures)

15
Carbon nanostructures
Ordered carbon structures beyond graphite and
diamond
C60 Carbon Discovered in 1985
Carbon Nanotubes Disocovered in 1991
16
The formation of tubular structures from 2D
surfaces
17
Inorganic nanostructures
Nano-metric structures could be formed by other
2D materials
MoS2 fullerene-like nanoparticles
Nanotube WS2
18
Overview of potential applications

• lt AFM Tip
• gt Molecular electronics
• Transistor

• gt FED devices
• Displays

• lt Others
• Composites
• Biomedical
• Catalyst support
• Conductive materials
• Solid lubricants

• lt Energy storage
• Li-intercalation
• Hydrogen storage
• Supercaps

19
Quantum dots
20
The use of S-layer as lithographic mask
21
Bionanotechnlogy vs. Nanobiotechnology

• Biotechnology is an old field of research
• Nanotechnology offers new directions
  (lab-on-a-chip, NEMS, nano-arrays, quantum dots,
  etc.)
• Bionanotechnology The use of biological and
  bio-inspired assemblies for nanotechnological
  applications. For example Nanoelectronics,Nanowir
  es, wiring by DNA specificity, Molecular
  lithography

22
Bionanotechnlogy vs. nanobiotechnology
23
(No Transcript)
24
Cell based Bio-chips
Electronic component (chip)
Bacteria cells, human cells etc.
25
(No Transcript)
26
Physiological nanomachines and their
nanotechnological use

• A 750 nm long nickel propeller
• attached to motor protein

27
Self-Assembly and Nanotechnology

• Biology uses a bottom-up assembled strategy
• The unique properties of the DNA and protein
  building blocks
• Introduction to molecular recognition and
  self-assembly
• The chemical perspective of self-assembly
• The self-assembly of physiological, pathological,
  and viral entities and their nanotechnological
  use
• The design of self-assembling peptides and their
  nanotechnological applications
• Prospects for future nanotechnology industry

28
Top-Down vs. Bottom-Up
29
Biology had evolved bottom-up strategies from
the nanometeric to metric scales
30
The levels of information in biological systems
ROM
RAM
Running Program
31
Each cell contains all the molecular data for
functioning
The number of bases is each human cell is about
3.2 billion
32
The data is stored in a four letters code
33
(No Transcript)
34
(No Transcript)
35
Direct Nanotechnoligcal applications of the DNA
specificity