Introducing Rheumadrin

1
Introducing Rheumadrin

• Rheumadrin is an all natural proprietary
  ingredient, that has been clinically proven to
  reduce pain and rapidly promote joint health,
  improving flexibility and mobility. Clinically
  studied at various times in Vivo, it has been
  published TWICE in the prestigious Journal of
  Rheumatology.
• Available for oral and topical applications,
  Celadrin's beneficial effects have been proven
  superior in results to Glucosamine, Chondroitin,
  MSM, SAMe and other arthritic medications.

2
What Is Rheumadrin?

• Rheumadrin is comprised of novel, targeted
  proprietary cetylated fatty acid esters other
  active synergists.
• Rheumadrin 's proprietary compound is
  scientifically designed to be absorbed rapidly
  and provide immediate and continuous/cumulative
  pain relief.
• Rheumadrin , available for either oral or
  topical applications, enhances cell membranes
  throughout the body and restores fluids that
  cushion bones and joints to promote flexibility
  and mobility without pain.
• Rheumadrin has been shown to be very safe
  efficacious as evidenced by gold standard,
  double-blind, placebo-controlled clinical
  scientific studies.
• Rheumadrin is FDA compliant and non
  prescriptive.

3
Benefits of Rheumadrin

• Clinically shown for being fast acting (within 30
  minutes) with rapid and deep absorption/penetratio
  n to the affected area
• Clinically proven effective in both oral and
  topical applications
• 100 of the patients in the study on the
  proprietary cream showed significant benefit
  compared to the patients on the placebo
• Celadrin will provide speedy relief to aching,
  painful joints, muscles and tissues
• No reported negative side effects over 100
  million Rheumadrin pills distributed to date
• For temporary relief of minor aches and pains
  associated with simple backache, arthritis,
  strains, bruises and sprains
• Tremendous market potential, "joint functions and
  mobility challenges" are a growing segment of
  muscular-skeletal health challenges that are
  estimated to cost 250 billion dollars annually,
  in the U.S. alone

4
Mechanisms of Action

• The fatty acid complex found in Rheumadrin is
  distributed within the various tissues as
  determined via our radiolabel research. It seems
  likely that the majority of the product is
  processed within the liver. The resulting
  chylomicrons are then distributed within the
  circulation and made available to the entire
  cellular matrix. In addition, it is very likely
  that with both oral and topical use, there is
  distribution within tissue spaces prior to the
  first pass through the liver.
• There is clinical data that Rheumadrin can
  induce, beneficial alterations in the cellular
  membrane.

5
Market Potential for Rheumadrin

• Over 70 million individuals in U.S. have
  arthritis (Center for Disease Control).
• The Arthritis Foundation reports that arthritis
  is the leading disability of Americans, resulting
  in over 39 million medical visits/year and 65
  billion dollars annually in medical expenses and
  lost wages.
• Joint functions and mobility challenges are a
  growing segment of musculo-skeletal health
  challenges that are estimated to cost 250
  billion dollars in the U.S. alone.
• Rheumadrin provides restoration of arthritic
  conditions for a much larger potential market
  than Glucosamine.
• Rheumadrin could be added to current leading
  compounds (Chondroitin, Glucosamine, SAMe, etc..)
  or product formulas, to increase efficacy and
  product sales.
• For Marketers involved in veterinary sales,
  Rheumadrin has been studied to be effective in
  canines. The canine population in the U.S. is 53
  million, 20 of which suffer from osteoarthritis
  (OA). Rheumadrin can be proven to be more
  effective than Glucosamine and Chondroitin
  products, currently sold in this market segment.

6
Conditions Rheumadrin Glucosamine
Alleviate
Market Potential for Rheumadrin
Estimated size of pain pie population is 120
million
7
RHEUMADRIN COMPARISON TO COMPETITIVE COMPOUNDS
Market Potential for Rheumadrin
8
Scientific Studies

• Scientific Evaluations of Rheumadrin have
  demonstrated
• Esterified Fatty Acid Complex (EFAC) found in
  Rheumadrin can be effectively absorbed in
  either oral or topical form and delivered to the
  required area of pain in the body.
• In clinical studies using oral and topical
  applications, patients with chronic knee problems
  and Osteoarthritis (OA) produced significant
  improvement in knee movement, the ability to
  climb and descend stairs, rise from chairs,
  improvement in walking, balance, strength and
  endurance. More significant was that in one of
  the studies, patients were already consuming
  arthritis medications (Aspirin, Ibuprofen or
  Celecoxib) and still demonstrated significant
  improvement with Rheumadrin .
• Product safety confirmation through Acute
  Toxicity testing and Ames test screening have
  been conducted.

9
Scientific Studies
Scientific Evaluations of Rheumadrin have
demonstrated (continued)

• No adverse effects or reactions such as upset
  stomach (oral) or skin irritations (topical).
• Anti-aging potential benefits were observed in
  laboratory mice by measuring skin thickness.
• A 30 day canine study of Rheumadrin , using 24
  arthritic dogs resulted in a 75 improvement in
  the quality of life of the pets, as noted by
  their owners. Dogs appeared "happier", "more
  energetic", had "better temperament" and an
  overall improved "Quality Of Life (QOL)".
• A small (14 subject) placebo controlled blind
  study, using Rheumadrin Cream showed measurable
  improvement in subject's with severe psoriatic
  condition.

10
Scientific Studies

• Kraemer WJ, Ratamess NA, Anderson JA, Tiberio DP,
  Joyce ME, Messinger BN, French DN, Sharman MJ,
  Rubin MR, Gomez AL, Volek JS, Hesslink R Jr.
  (2003) The effects of cetylated fatty acid cream
  on pain, range of motion and quality of life of
  patients with osteoarthritis. American College of
  Sports Medicine, San Francisco, CA.
• A 30 day study conducted on patients with
  (OA) in both knees. Conclusion, use of EFAC
  cream is an effective treatment for improving
  knee (ROM) movement, ability to ascend/descend
  stairs, rise from a chair, walk and improve
  balance, strength and endurance.
• Ratamess NA, Kraemer WJ, Anderson JA, Tiberio DP,
  Joyce ME, Messinger BN, French DN, Sharman MJ,
  Rubin MR, Gomez AL, Volek JS, Hesslink R Jr.
  (2003) The effects of a cetylated fatty acid
  cream on functional mobility and performance in
  patients with osteoarthritis. American College of
  Sports Medicine, San Francisco, CA.
• This Rheumadrin cream study concluded that
  the use of EFAC topical cream produced
  significant improvement in stair climbing
  ability, standing balance, local muscular
  endurance and ability to rise from a chair and
  walk, in patients with OA.

11
Scientific Studies

• Islam A, Gallaher C.M., Gallaher D.D. (2003)
  Absorption metabolism of a cetylated fatty
  acid. Experimental Biology, San Diego, CA.
• This study successfully measured the
  absorption of EFAC in 10 rats using topical and
  oral applications. It was proven that EFAC could
  be absorbed by either method (95.1 absorption of
  radio labeled EFAC's).
• Gallaher D.D., Gallaher C.M., Hesslink R. Jr.
  (2002) Digestion and metabolism of cetylated
  fatty acids in rats. Experimental Biology, New
  Orleans, LA
• Successfully demonstrated oral absorption
  of EFACs.
• Hesslink R.L., and Sprouse S. (2002) The effects
  of a cetylated fatty acid complex on canine
  osteoarthritis. 2nd International Symposium on
  Rehabilitation and Physical Therapy in Veterinary
  Medicine, Knoxville, TN.
• 30 day trial of 24 arthritic canines.
  Owners noted 75 improvement in quality of life,
  energy movement.
• Barathur R. R., Bookout J.B., Sreevatsan S,
  Freedland E.S. and Hesslink Jr., R.L. (2001). A
  fatty acid ester (CMC) improves quality of life
  outcomes in osteoarthritis (OA) patients.
  Experimental Biology, Orlando, FL.       

12
Publications

• Kraemer W.J., Ratamess N.A., Anderson J.A.,
  Maresh C.M., Tiberio D.P., Joyce M.E., Messinger
  B.NB., French D.N., Sharman M.J., Rubin M.R.,
  Gomez A.L., Volek J.S. Hesslink, Jr., R.L.
  (2003) The effects of a cetylated fatty acid
  topical cream on functional mobility quality of
  life of patients with osteoarthritis. In review,
  J. Rheumatology
• Topical Cream Study no menthol.
• Hesslink Jr. R.L., Armstrong III D.A., Nagendran
  M.V., Sreevatsan S, Barathur R. (2002)
  Cetylated fatty acids improve knee function in
  patients with osteoarthritis. J Rheumatology,
  291708-1712
• 64 patients with chronic knee problems at
  30 68 days (also placebo group - 33 Celadrin -
  31 vegetable oil). Results significant increase
  in knee flexatition with Rheumadrin. More
  significant was that patients were consuming
  arthritis medication such as Aspirin, Ibuprofen
  and Celecoxib.
• Islam A, Gallaher C.M., Gallaher D.D. (2003)
  Absorption metabolism of a cetylated fatty
  acid. FASEB J. 17(4) A341
• Gallaher D.D., Gallaher C.M., Hesslink R. Jr.
  (2002) Digestion metabolism of cetylated fatty
  acids in rats. FASEB J. 16 (4) A365
• Barathur R.R., Bookout J.B., Sreevatsan S,
  Freedland E.S. Hesslink Jr., R.L. (2001). A
  fatty acid ester (CMC) improves quality of life
  outcomes in osteoarthritis (OA) patients. FASEB
  J. 15(4) A265

13
Technical Reports

• Bacterial reverse mutation Ames test screening.
  (2002) MDS Pharma, Les Oncins, France.
• Evaluation of topical cetylated fatty acid
  application to psoriasis patients. (2002)
  Dermatologist Medical Group of North County, Inc.
  
• A small placebo controlled blind study using
  Rheumadrin cream experienced measurable
  improvement in their psoriatic condition.
• The acute toxicology of oral cetylated fatty acid
  gavage CD-1 mouse model. (2001) Perry Scientific,
  Inc., Study No. 00-1075.
• Evaluation of a topical cream containing
  cetylated fatty acids using hairless mouse model.
  (2000) Perry Scientific, Inc., Study No. 00-1076.
  
• Objectives were to assess potential skin
  irritations, cellular pathology and skin aging.
  Mice were measured at 10, 58 and 144 days. Mice
  behavior was normal, no signs of skin irritations
  or abnormalities in cell lines. Anti-aging
  benefits were observed measuring the comparative
  skin thickness of the mice.