??????? ????????? pseudomonas aeruginosa ??????????? ?????????

1
??????? ????????? pseudomonas aeruginosa
??????????? ?????????

• ???????
• Kingdom Bacteria
• Phylum Proteobacteria
• Class Gamma Proteobacteria
• Order Pseudomonadales
• Family Pseudomonadaceae
• Genus Pseudomonas
• Species P. aeruginosa

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2
??????? ????????? pseudomonas aeruginosa

• ????? ???????? ?? ??? ????
• ?????? ????? ????? ?????? ???? pseudomonas ????
  ???? ????? (false unit ) ??? ???? ?????????
  pseudo ???? ? monas ????? ????? ? ?????? ????????
  ?????? ?? ?????? ????? ??????? ???????? ???????
  ??? ?????????.
• ?????? ?????? ????? ?????? ???? aeruginosa ????
  ?????????? ???????? ( ??? ????? ) ??? ??????
  ??????? ?????????? ???????? ???????? ????? ??
  ??????? ???????? ??? P. aeruginosa.

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3
??????? ????????? pseudomonas aeruginosa

• ??????? ?????? Characteristics
• ??????? ????? ???? ???? ??? ????? ?????? ????????
  ??????? ?????? ??????. ???? ????? ????????
  ???????? P. aeruginosa ????? ???? ????? ????????
  ???????.

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4
??????? ????????? pseudomonas aeruginosa

• ??????? ?????? Characteristics
• ???? ?????? ???? ???? ??? P. aeruginosa ?? ????
  ???? ????? ???? ????? ???? ????? ? ??? ???????
  ??????? ?????? ?? ?? ???? ????? ???????????
  ?????????? ???????? ??? ???? ?????? ?? ???? ???
  ???? ????? 42CO .

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5
??????? ????????? pseudomonas aeruginosa

• ??????? ?????? Characteristics
• ??????? P. aeruginosa ????? ??? ????? ??
  ??????? ??????? ???????? ??? ?????? ????
  ????????? ?????? ???????? ?????? ?????????????
  (or "HUM bugs") .
• Pseudomonas aeruginosa ?????? ??? ????????
  ?????????? Pseudomonadaceae. ???????? ????????
  ?????? ??????????? ????? ?????? ?????? ?? ???????
  ???????.

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6
??????? ????????? pseudomonas aeruginosa

• ??????? ?????? Characteristics
• Pseudomonas aeruginosa ???? ???? ?????? ??????
  ??? ???????????. ????? ??? ?? ?? CDC? ???????
  ??????? ???????? ?? P. aeruginosa ?? ???????
  ?????????? ?????????? ????? 0.4 ??????? (4 ????
  1000 ??????)? ? 10.1 ??????? ???? ??????
  ??????????? ????????.

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7
??????? ????????? pseudomonas aeruginosa

• ??? ?????????? ??????
• P. aeruginosa ??? ????? ???? ????? 3 ????? ??
  ??????????. ???????? ??????? ???? ??????? ???
  ?????? ???????? ????? ????? ????? ???? ???????
  ???? rough colony. ??????? ????????? ????????
  ???? ?? ???? ????? ?? ?????????? ??????? ?? ?????
  smooth colony . ??? ??? ?????????? ???? ?????
  ???? fried-egg??? ???? ????? ???????? ?????????
  ????????? ?????? ??????. ????? ?????? ?????
  ?????? ???? ???????? ???????? ?????????
  ?????????? ???? ????? ????? mucoid ? ????
  ???????? ??? ?????? ???? alginate. ??????????
  ??????? ????????? ??????? ?????? ??? ??
  ?????????? ????????.

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8
??????? ????????? pseudomonas aeruginosa

• ??? ?????????? ??????

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9
??????? ????????? pseudomonas aeruginosa

• ??? ?????????? ??????
• P. aeruginosa ???? ?? ???? ????? ???? ??????
  ???????? ??????? ????????? ?????? ??????
  pyoverdin ??????? ??????? pyocyanin. ???????
  ??????? ????? ???? ????? ????? ??? ???????
  ??????? ? ?????? ?????? ?????? ?? ?????????.
  Pyocyanin (???? "pyocyaneus" ) ?????? ??? "???
  ????" "blue pus" ???? ??? ??? ??????? ??????
  Pseudomonas aeruginosa .

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10
??????? ????????? pseudomonas aeruginosa

• ????? ???? P. aeruginosa
• ??????? ??? ?????? ???????? ?????? ?????????.
  ????? ?????? ??? ???? ????? ?????? ????? ???
  ????? ???? ?????? ??? ???? eosin methylthionine
  blue. ?? ????????? ??? ???? ????? ????? ???????
  ???? ??????? ??? ???????? ??????? ?????????
  ferment lactose , ????? ?????? ?????? ??????????
  oxidase ? ??????? ???? ???????? ??????? ???????
  ?? 42Co. ????? ??? ?????? ??? ?????????? ??????
  ?? ???????? ???????? ?????????? ??????? ?????
  ????????? ???????? ????? P. aeruginosa ??
  ???????.

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11
??????? ????????? pseudomonas aeruginosa

• ?????? ?????? ???????? Pathogenesis
• P. aeruginosa ??? ??????? ?????? ????????
  ???????? ????????? ???????? ???????? ????????
  ???????? ???????? ??????? ?????? ?????? ?????.
  ???? ?? ???? ?????? ??????? ????????? ????
  Pseudomonas. ???? ???? ???? ????????? ????? ???
  P. aeruginosa . ???? ??????? ???? P. aeruginosa.
  ????? ?????? ???????? "??? ???? ?????" (??????
  ???)? ???? ???? ????????? ??????? ??????? ???????
  ????????.

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12
??????? ????????? pseudomonas aeruginosa

• ???????? ??????? ???????? ?????????
•   Pseudomonas aeruginosa ?????? ?????????? ???
  ???????? ??????? ?? ??? , ???? ????? ?????
  ??????? ????. ??? ????????? ??????? ??????? ???
  ?????? ???? ???????? ??????? ???? ????? ????????
  ???????? ??????? outer membrane LPS ( ?? ????
  ????? ???????? ). ?????? ????? ???????????
  ??????? ?? ?????? ???????? ( ???????? ) biofilm
  ???? ??????? ??????? ????? ??? ?????? ???????????
  ??????? ??????????. ??????? ????????? ????????
  ?????? ????????? ?? ???????? ? ?????? ??????? ??
  ????? ?????? ??????? ????????. ????? ??? ????
  ???? Pseudomonas ?????? ?????? ?????? ?????????
  plasmids? ???? R-factors and RTFs? ??? ???? ???
  ?????? ??? ?????? ???? ????????? ?????????? ?????
  ?? ?????? ?????????.

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