Sarcoidosis

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Sarcoidosis

• Bryan Imayanagita
• 10/22/10
• UCI T-RAP

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Background

• Besnier-Boeck disease
• Abnormal collection of inflammatory granulomas
• 20-40 years year old. Scandinavian, blacks
• Commonly affects lungs

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Pathophysiology

• Exact cause unknown
• accumulation of monocytes, macrophages and
  activated T-lymphocytes
• Macrophage increase inflammation while immune
  response suppressed
• Genetic Factors BTNL-2 gene (possibility)

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Symptoms

• Signs often vague and hard to distinguish
• Fatigue, aches, pains, rashes
• Enlarged lymph nodes
• Mimics cancer
• Can be asymptomatic

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Diagnosis

• Process of elimination
• CT, chest X-ray, PET scan to exclude in pulmonary
  cases
• Differential diagnosis metastatic disease,
  lymphoma, septic emboli, etc
• Women association with hypo/hyperthyroidism

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Stage IV Sarcoidosis
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Treatment

• 30-70 dont require treatment
• Corticosteroids (prednisone)
• Follow up EKG, liver, calcium tests

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Prognosis

• Can remit spontaneously or become chronic
• Half cured in 12-36 months. Most in 5 years
• heart problems
• Higher cancer risks

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Sources

• http//www.merck.com/mmhe/sec04/ch050/ch050e.html
• http//www.nhlbi.nih.gov/health/dci/Diseases/sarc/
  sar_signsandsymptoms.html
• http//www.medicinenet.com/sarcoidosis/article.htm