METHYL ALCHOL ( METHANOL)

1
METHYL ALCHOL ( METHANOL)

• 
  
  
• Arun Gautam
• Roll No. - 17

2
introduction

• Also known as wood alcohol, wood spirit, wood
  naptha carbinol
• Prepared by destructive distillation of wood
  molasses
• It is light, volatile, colorless, nauseous taste,
  flammable, poisnous liquid with a very faint odour

3
USES

• Solvent for gums, fat varnishes
• Denaturation of ethyl alcohol
• Methlyated spirit
• - 95 ethyl
  alcohol
• - 5 wood naptha
• - 0.5 crude
  pyridine
• Solvent and as a antifreeze in pipelines

4
toxicity

• Formic acid Formaldehyde are toxic products
• Toxicity result by
• - ingestion
• - inhalation
• - absorption
  through
• skin
  

5
Mode of action

• Cumulative poison
• Rapidly absorbed through GIT, lungs skin
• Oxidised to formic acid formaldehyde with the
  production of lactic acid
• IT CAUSES
• - metabolic acidosis
• - degenrative changes in
• internal organs retina

6

• Fatal dose 60 240mL
• 15mL cause blindness
• Fatal period 24 - 36 hrs

7
SIGN SYMPTOMS

• Headache, dizziness, vertigo
• Nausea, vomiting epigastric pain
• Cardiac functions are depressed
• Muscular weakness, dyspnoea cyanosis
• Visual disturbances
• - blurred
  vision
• -
  photophobia
• - optic
  neuritis

8
Contd..

• Subnormal temperature
• Delirium coma (2-3 days)
• Bradycardia KUSSMAUL BREATHING
• Urine is strongly acidic and contains
• -
  albumin
• 
  - acetone
• 
  - formic acid
• Death occurs from respiratory failure

9
treatment

• Protect eyes from light
• Maintain ventilation BP
• Gastric lavage 5 Sod. Bicarbonate in warm
• water
• Sod. bicarbonate to combat acidosis
• 50 Ethanol (oral)
• loading dose 0.75- 1 ml/ kg
  bd. wt.
• maintenance dose 0.15ml/ kg bd. wt.
• 4- methylpyrazole
• Haemodialysis

10
AUTOPSY FINDINGS

• Stomach intestine are hyperaemic,
• congested and inflamed with patchy
• submucous haemorrhage
• Brain, meninges, lungs kidneys are
• congested and oedematous
• Blood is generally fluid dark
• Oedema of optic disc optic nerve atrophy

11
Medicolegal aspects

• Poisoning is always accidental
• Mass poisoning result from consumption of liquor
  adulterated with methyl alcohol
• Consumption of SOLOX KHOPADI

12
thanks