???IN??~~ CoQ10

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???IN?? CoQ10

• ?????
• Nano CoQ10 ???,?????
• ??NT3,000? ! ?????15,000?
• 2004?,CoQ10?????????NT29?

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CoQ10 ???
????????
??CoQ10(Coenzyme Q10)???,??,??????,??????
?????????
CoQ10 (CoEmzye 10? ??Q10????Q10)
??????????????????
?????????
????????????????
?????????????
??????
????????????????
??????????????????????
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??? CoQ10?

• ??Q10 (Coenzyme Q10)
• ????????,????
• ????????????????,????
• ?????,?????(?????)

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??? CoQ10?

• ?????????????,?????????,CoQ10???????,???????

• ??Q10 ??????????????????,???????,?????????,???????
  ??

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??? CoQ10?

• CoQ10 ??20????,???????,?80?????35
• ????,?CoQ10?????25,???????!

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????CoQ10

• ???????????CoQ10,????
• ??30??,???
• 681???????18????(????6?)
• 908???????113.5???(????1?),
• 5108?????!
• 1.14?????
• ?????!

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CoQ10 ???

• ?CoQ10 ??????,?????????
• ?? , ???

???CoQ10??????,????
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(No Transcript)
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??????

• ??????,???????????
• ????1nm10-9m
• ??????? ? ???
• ?????????????????,??????????????,????????,??????
  ??

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??????
????
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CoQ10 ??
???Cyclodextrin


CoQ10
CoQ10


hydrophobic
???
???
??CoQ10??????,????
CoQ10?????,?????
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(No Transcript)
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?????
??????????????????10???,???????
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??
???? (?????)
???
COQ10
???
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?????CoQ10 ????
??????CoQ10 (???/???)
CoQ10?????10???
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CoQ10 ?????

• ??????
• ????????????? ?
• ??????
• ?????????????(???)
• ?????ATP????(??????,??????)
• ????
• ?????E?????????
• ??????
• ?????????
• ????????

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CoQ10 ?????????
????????
??????
???? ????
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??????

• CoQ10???????
• CoQ10????????????
• ?CoQ10 has been shown to significantly help
  those with congestive heart failure (CHF)1
• ? Potent benefits for CHF patients2
• 9????????????????
• ??VitE??

1 Mortensen SA, et al. Drug Exptl Clin Res
19851158193.2 Soja AM, Mortensen SA. Ugeskr
Laeger 199715973028.
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CoQ10???????????

• ????????-??????
• ???????CoQ10 100??,????????????????CoQ10??????????
  ???????????
• ??????,??CoQ10?????,????????????
• Ref Poggesi L, Galanti G, Comeglio M, et al.
  Effect of Coenzyme Q10 on left ventricular
  function in patients with dilative
  cardiomyopathy a medium-term randomized
  double-blind study versus placebo. Current
  Therapeutic Research 199149878-86.

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CoQ10???????????

• ??-????
• ???????150-200???CoQ10,????5-7?(???1,000??),??????
  ?????????????CoQ10?????????????????????????????
• Ref Chen YF, Lin YS, and Wu SC. Effectiveness of
  conenzyme Q10 on myocardial preservation during
  hypothermic cardioplegic arrest. Journal of
  Thoracic and Cardiovascular Surgery
  1994107242-47.

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CoQ10????????????

• 10????,????2?50??CoQ10
• ????????????????CoQ10??????????(??????10,HDL??9
  )????????
• RefDigiesi V, Cantini F, Bisi G, et al.
  Mechanisms of action of Coenzyme Q10 in essential
  hypertension. Current Therapeutic Research
  199251668-72.

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???? ????

• ????CoQ10??????10???????????????????,????????,???
  ??????
• CoQ10????????????
• ?????,CoQ10?????
• ?????????????
• ???????
• ??????
• CoQ10??????????????????? ?,?????????,?????????
  ?
• Passi S, De Pita O, Grandinetti M, Simotti C,
  Littarru GP. The combined use of oral and topical
  lipophilic antioxidants increases their levels
  both in sebum and stratum corneum. BioFactors
  200318289-97.
• Passi S, De Pita O, Puddu P, Littarru GP.
  Lipophilic antioxidants in human sebum and aging.
  Free Radic Res 200236471-7.
  

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???? ????

• CoQ10??????????
• ?????????,????360mg CoQ10??4?,???????????
• ?????????????????
• Huntingtons Disease patients1
• Parkinsons Disease and Friedreichs ataxia2-3
• ???????????Alzheimers Disease and other
  dementia4-6

1 Andrich J, et al. J Neural Transm Suppl.
2004(68)111-6. 2 Beal MF, Shults CW.
Biofactors. 200318(1-4)153-61. 3 Shults CW.
Curr Med Chem. 2003 Oct10(19)1917-21. 4
Koroshetz WJ, Jenkins BG, Rosen BR, Beal MF. Ann
Neurol. 1997 Feb41(2)160-5. 5 Shults CW, et al.
Arch Neurol. 2002 Oct59(10)1541-50. 6 Shults
CW, et al. Exp Neurol. 2004 Aug188(2)491-4.
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CoQ10 ??????

• Andrich J, Saft C, Gerlach M, Schneider B, Arz A,
  Kuhn W, Muller T. Coenzyme Q10 serum levels in
  Huntington's disease. J Neural Transm Suppl.
  2004(68)111-6.
• Beal MF, Shults CW. Effects of Coenzyme Q10 in
  Huntington's disease and early Parkinson's
  disease. Biofactors. 200318(1-4)153-61.
• Beal MF. Coenzyme Q10 administration and its
  potential for treatment of neurodegenerative
  diseases. Biofactors. 19999(2-4)261-6.
• Hoppe U, Bergemann J, Diembeck W et al. Coenzyme
  Q10, a cutaneous antioxidant and energizer.
  BioFactors 19999371-8.
• Passi S, De Pita O, Grandinetti M, Simotti C,
  Littarru GP. The combined use of oral and topical
  lipophilic antioxidants increases their levels
  both in sebum and stratum corneum. BioFactors
  200318289-97.
• Passi S, De Pita O, Puddu P, Littarru GP.
  Lipophilic antioxidants in human sebum and aging.
  Free Radic Res 200236471-7.
• Poggesi L, Galanti G, Comeglio M, et al. Effect
  of Coenzyme Q10 on left ventricular function in
  patients with dilative cardiomyopathy a
  medium-term randomized double-blind study versus
  placebo. Current Therapeutic Research
  199149878-86.
• Chen YF, Lin YS, and Wu SC. Effectiveness of
  conenzyme Q10 on myocardial preservation during
  hypothermic cardioplegic arrest. Journal of
  Thoracic and Cardiovascular Surgery
  1994107242-47.

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CoQ10 ????

• ?????????????????,???CoQ10?????????,????????,????
  ????
• ??????????????????????10???,???????,?????????????
  ????
• ?????????????E??????????
• ??????????,????????
• ??????????,??????
• ???????????,?????????????
• ?????????????

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CoQ10

• ??
• ??CoQ10??????????
• ??CoQ10??????????
• ??CoQ10??????????
• ????????,????

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??????
?? CoQ10(????) A?(????) B? (????) C? (????) D? (??)
CoQ10??/? 30mg 30mg 15mg 3mg 30mg/?
CoQ10??/? 30mg 30mg 30mg 6mg 30mg
???? ? x x x x
?? NT1,600(30?) NT1,900(30?) NT999(60?) NT1,200(60?) NT350 (50ml6)
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??????
?? CoQ10(????) A?(????) B? (????) C?(????) D?(??)
?? NT1,600(30?) NT1,900(30?) NT999(60?) NT1,200(60?) NT350 (50ml6)
??CoQ10 30mg/?? NT53 NT63 NT33 NT200 NT58
??????????????? ??????????????? ??????????????? ??????????????? ??????????????? ???????????????
??/? NT53 NT630 NT330 NT2,000 NT580
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????
????????????
????????? ???? Inside and Out.
CoQ10???????? CoQ10?????
??? Q10 (CoQ10) ???????? ????C?E
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?????

• ??????????
• (?????)
• ????????????
• ?,????????
• ???C?E(?????)

Vitamin E
CoQ10
Vitamin C
CoQ10
Vitamin C
Vitamin E
(Carotenoids)
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????
1.????????,??????, ????????????2.??????????????
? ?????,????????
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?????- ?????

• CoQ10??????????????????????????????
• CoQ10 is an example of an antioxidant that
  has been put to the test by innovative
  researchers and physicians and has passed with
  flying colors.
• - ?????
• Dr. Lester Packer, PhD

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????????? ????

• ???????????????????CoQ10

?????