(?)?????(nuclear magnetic resonance,NMR)

1
(?)?????(nuclear magnetic resonance,NMR)

• ????????????(?1H?13C?)???????????,????????????????
  ?????????????,??????????????????????,?????????????
  ??????????????,????(1H-NMR)???????,????(13C-NMR)??
  ????????,??????????????????????

2
500Mhz????????
3
1.??

• (1)???????????????1H?,?????????????(?????????????
  ???)??,??????????????????????d??,???ppm?1H-NMR????
  ?????020ppm????????????,???????????(TMS)???????,?
  ??????????????????

4
(No Transcript)
5
(2)??????????

• ???????????1H?,?????????????????????????,??????,??
  ????(s),?????????????????,????(d)????(t)????(q)???
  ?(m)??????????,?????????????????(n)??,??n1??,????
  ??????? n1? ???(-CH2CH3)?,????????????,??????31
  ,??????????????21,??????

6
(3)???

• ?1H-NMR??,?????????????????????????????1H???,??,??
  ???????????,?????????1H????????,??????????????????
  ??1H????

7
(No Transcript)
8
2.??

• ????????????????????????????????,13C-1H???????????
  ???13C-NMR????????,???????13C???????

9
(?)??(mass spectrometry, MS)

• ???????????????,????,?????,?????????????(m/z)?????
  ?,????????????????????????????????????????????????
  ?,????,?????,?????,???????????????????????????????
  ???????????

10
???
11

• ????????????????????????????? ?
• ???????????????????

12
(No Transcript)
13

• ????,????????????????????????,????????????,???????
  ????????????????????????,?????????????????????

14

• ???
• 1.???????????????????
• 2.??????????????????????????????
• 3.????????????????
• 4.???????????????????????
• 5.???????????????????
• 6.??????????????
• 7.????????????????????
• 8.????????????????,??????????????