Comparative Vertebrate Physiology - PowerPoint PPT Presentation

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Comparative Vertebrate Physiology

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Times New Roman MS P Arial Wingdings Times Network 1_Network DeltaGraph Equation Comparative Vertebrate Physiology Neuron anatomy and signaling ... – PowerPoint PPT presentation

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Title: Comparative Vertebrate Physiology


1
Comparative Vertebrate Physiology
  • Action potentials

2
Neuron anatomy and signaling
3
Action potential
Depolarization Repolarization Hyperpolarization
4
Action potential
  • Phases
  • Resting membrane potential
  • Depolarization
  • Repolarization
  • Hyperpolarization

5
Nernst equation
  • Measures equilibrium potential
  • Depends on
  • absolute temperature
  • valence
  • ratio of concentration gradients

6
Nernst equation
  • If Ko 0.01M and KI 0.1M

7
Action potential
  • Hodgkin and Huxley theory
  • Resting membrane potential

8
Action potential
  • Resting membrane potential

9
Action potential
  • Hodgkin and Huxley theory
  • Depolarization rising phase Na (5,000x)

10
Action potential
  • Hodgkin and Huxley theory
  • Repolarization falling phase K (10x)

11
Action potential
  • Hodgkin and Huxley theory
  • Hyperpolarization

12
Membrane permeability
13
Protein gates
  • Types
  • Chemical
  • Occur between neurons
  • Voltage
  • Occur within neurons

14
Voltage gates
15
Refractory period
  • Absolute
  • Na activation gate open
  • Relative
  • Na activation gate closed

16
Channel toxins
  • TTX (tetradotoxin)
  • Japanese puffer fish
  • decreases Naconductance
  • increases Kconductance

17
Channel toxins
  • TEA (tetraethylammonium)
  • Synthetic organic compound
  • increases Naconductance
  • decreases Kconductance

18
Channel toxins
19
Threshold
  • An all-or-none event

20
Threshold
  • Factors effecting
  • Magnitude
  • Duration

21
Excitation curve
22
Impulse conduction
23
Impulse conduction
  • Schwann cell secrete myelin

24
Conduction velocity
  • Mylenated 15 - 40 msec-1
  • Unmylenated 0.4 - 0.5 msec-1
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