The Nobel Prize in Physiology or Medicine 1998

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The Nobel Prize in Physiology or Medicine 1998

• discoveries concerning nitric oxide
• as a signaling molecule in the cardiovascular
  system

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What is NO?

• Nitric oxide (NO)????????????????????????????????
  ????NO??????????1998???????????
• NO??????????????,?????????? ,?????????????????

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NO (Nitric Oxide) ??????

• ?NO???????????

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(No Transcript)
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1998???????

• ????????????????

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1998 ?????????


Robert F. Furchgott Ferid Murad Louis J Ignarro
b.1916 USA b.1941 USA b.1936 USA
SUNY Health Science Center Brooklyn, NY University of California School of Medicine Los Angeles, CA University of Texas Medical School at Houston Houston, TX
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1998 ?????????(Robert F. Furchgott)

• 1953 ?????????????????????
• 1978 ???? David Davidson?????????,???????????????
  
• Furchgott??????????????????????????????????????,??
  ?????????

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1998 ?????????(Robert F. Furchgott)

• ???????????????????????? --??????????(EDRFendothe
  lium derived relaxing factor),???????????,???????
  
• 1980?,????????????????????EDRF??????????

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Furchgott's sandwich
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Robert Furchgott ?????
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?????????????????????????????,???????????????????
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???????,????????,???EDRF?EDRF ??????????????????
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??EDRF??????????????,???????guanylyl
cyclase???????????
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?guanylyl cyclase????,???GTP??cyclic GMP Cyclic
GMP,??????????myosin(??????????????)?
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?myosin?????,?????????????????,??????
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1998 ????????? (Ferid Murad)

• ?1970 ???????????????? (NO,Nitric Oxide) ? cGMP
  (??????????) ?????? (signal transduction) ????
• ?? 1977 ????????? (J Cycl Nucl Res)
  ????????????????????????????????,??,?????????????,
  ???NO??????

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??? Ferid Murad

• cyclic GMP
• How do small molecules regulate the activity of
  the enzyme guanylyl cyclase
• (GTP ? cGMP) and cyclic GMP synthesis?
• What are some biological functions of increased
  cyclic GMP levels?