Drug Formulation / Drug Delivery

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Drug Formulation / Drug Delivery

• Raj Suryanarayanan (Sury)
• Department of Pharmaceutics
• College of Pharmacy
• surya001_at_umn.edu

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Faculty Research Areas

• Biological Pharmaceutics (Pharmacokinetics,
  Pharmacodynamics, Metabolism)
• Elmquist, Fairbanks, Sawchuk, Zimmerman
• Physical Pharmaceutics (Materials Science)
• Suryanarayanan, Sun
• Drug Delivery
• Kandimalla, Prabha, Panyam, Siegel, Wiedmann

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Center for Translational Drug Delivery

• Developing collaborative relationships with
  pharmaceutical companies in the area of drug
  delivery

Raj Suryanarayanan(Sury), Pharmaceutics Surya001_at_u
mn.edu
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Goals and missions of the Center

• Bring together faculty with interest in drug
  delivery
• Leverage our comprehensive expertise in drug
  delivery develop collaborations with
  pharmaceutical companies
• Work with the different administrative units to
  expedite legal and contractual issues
• Serve as a platform for training grants and
  program project grants that are focused on drug
  delivery

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AeroCore

• Supporting research and product development
  through inhalation drug delivery

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Core Activities

• Aerosol generation
• Characterization of aerosol particles
  (output/particle size distributions)
• Exposure of rodents to aerosol particles or
  vapors
• Measurement of chemicals deposited in the
  respiratory tract and accumulation in blood of
  rodents
• Gross and microscopic examinations of rodents
• Disease induction in animal models (e.g. cancer)

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• Drug solubilization through engineering solid
  form (nanocaging, solid dispersion,
  cocrystallization, salt formation, etc.)
• Tablet formulation and manufacturing process
  understanding and control
• Structure-mechanical property relationship in
  organic crystals and powders

C.C. Sun
The aqueous solubility of poorly soluble drugs is
significantly improved by nanocaging.
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Kandimalla lab drug delivery projects

• Design of nanotheranostics for the diagnosis and
  treatment of cerebrovascular diseases.
• Elucidation of biophysical properties of
  endogenous macromolecules and their transport
  across the cellular barriers, particularly the
  blood brain barrier.
• Development of novel drug delivery approaches to
  disrupt bacterial biofilms.
• Strategies to evaluate and enhance oxidative
  stability of natural carrier oils.

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Prabha Research Interests
Oral formulations to improve bioavailability of
poorly soluble drugs
Anti-angiogenic therapy for ovarian cancer
Sustained protein/gene delivery for chronic wounds
Photodynamic therapy for treating microbial
infections in chronic wounds
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Panyam Research Interests
Targeted Antibiotic Delivery for Chlamydial
Infections NIAID/NIH
Magnetic Hyperthermia for Lung Cancer Department
of Defense
Polymeric Systems for Cancer Prevention/Treatment
NCI/NIH
Targeting Cancer Stem Cells Randy Shaver
Foundation
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SIEGEL LAB

• Polymeric Drug Delivery Systems, Hydrogels
• Microfabricated Sensors (e.g. temperature, pH,
  glucose)
• Intranasal Delivery of Low Solubility, Fast
  Acting Drugs

Application Canine Epilepsy