Synaptic transmission

1
Synaptic transmission
2
Synaptic currents drive spike generation
3
Summation
4
Inhibitory synapses
5
Modeling synaptic inputs
spike input, u(t)
pre-
?
conductance change, g(t)
post-
alpha function
6
Modeling synaptic inputs
(1) spike input, u(t)
pre-
(2) low-pass filter, z(t)
(3) low-pass filter, g(t)
post-
alpha function
7
Modeling synaptic inputs
g(t) postsynaptic conductance change
(1) spike input, u(t)
pre-
(2) low-pass filter, z(t)
(3) low-pass filter, g(t)
post-
alpha function
8
Postsynaptic voltage update equation
9
Postsynaptic voltage update equation
pre-
ionic currents (e.g., Hodgkin-Huxley)
post-
10
Postsynaptic voltage update equation
pre-
ionic currents (e.g., Hodgkin-Huxley)
post-
synaptic currents
11
Reversal potential
12
(No Transcript)
13
Simple Networks / Reflexes
14
Flexor/crossed-extensor reflex
15
Central pattern generation
central pattern generator (CPG) -- a neural
circuit capable of producing repetitive activity
in the absence of any sensory input
16
Central pattern generation
17
Reciprocal Inhibition
18
Post-Inhibitory Rebound
19
Lobster Gastric Mill Networks