Nano-Bio-Info Technology

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Nano-Bio-Info Technology

• Foothill DeAnza Colleges
• Nanotechnology Program

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Nano-Bio-Info-Tech (NBIT)

• Fusion or convergence of
• Nanotechnology
• Biotechnology
• Information technology
• Focus of regional development
• Nanobiotechnology
• Bioinformatics and Informatics

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Some Definitions

• Bionanotechnology
• Biology as seen through the eyes of nano
• How do molecules work in biology?
• How can we make biology work for us?
• Applications
• Self assembled protein metal complexes
• DNA scaffolding for arrayed assembly

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Bio-Nano Convergence
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Bio-Nano Machinery

• Using protein / viral complexes and DNA to
  self-assemble devices, and novel function, into
  biomechanical systems

Earths early nanostructures 2 billion years ago
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Molecular Self Assembly
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Nano-Biotechnology

• Nanotechnology used in biotech
• DNA microarrays (GeneChip)
• SNP genotyping applications
• Silicon microtechnology for the lab
• Lab-On-A-Chip (LOC)
• System-On-A-Chip
• Biocompatible engineered surfaces
• Better performance / durability in humans

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Affymetrix GeneChip
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Bio-Nano-Info

• Looking at bio through the eyes of nano
• Physical properties of small / life systems
• Looking at nano through the eyes of bio
• Self-assembly of molecular nano structures
• Interaction of information and molecules
• Molecular assemblies as information and operating
  systems - nano execution of IT

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Nano-Bio-Info
Nano
Quantum computing nanoelectronic devices
Self assembly Microarrays, BioMEMS
Bio
Info
Digital cells DNA computing insilico biology
Concept by Robert Cormia
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Bio-Informatics

• Looking at life as an information system
• DNA as a database
• RNA as a decision network
• Proteins and genes as runtime DLLs
• Modeling gene regulatory networks
• Simulating life as a computer program
• Using silicon to validate biological models

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Digital Cells Bio Informatics
Modeling life as an information system
http//www.ee.princeton.edu/people/Weiss.php
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Nature as a Computer

• Biological systems like DNA and RNA especially
  appear to be more than networks of information.
• RNA itself can be seen as a molecular decision
  network

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Foothill DeAnza Programs

• Nanotechnology
• Intro to nanotechnology Fall 2005
• Certificate program in 2006 - 2007
• Biotechnology
• Full biotech program in 1995
• DNA, protein, microarray, bioinformatics
• Informatics
• Data mining and data warehousing

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Summary

• Nano-Bio-Info Technology
• Builds on nanotech and biotech
• Adds information tech to model systems
• NBIT going forward
• Building informatics into modified genomes
• Integrating biology and nanotechnology, working
  with life as an information system
• Stem cell work will be the next frontier