POXVIRIDAE

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POXVIRIDAE

• PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS
• Department of Pathology and Infectious Diseases,
  The Royal Veterinary College,
• Royal College Street,
• London NW1 OTU.
• E-mail Web site

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ObjectiveStudents should be able to

• Describe in outline the major pox virus
  infections of domestic animals

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Introduction
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Important diseases
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The virus and replication
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Recombinant vaccines
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Culture
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Pathogenesis
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Diagnosis

• By appearance, histology, em and now IIF or PCR

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COW POX
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ECTROMELIA

• (Mouse pox)

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ORF

• (Contagious pustular dermatitis, scabby mouth)

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ORF (cont.)

• (Contagious pustular dermatitis, scabby mouth)

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SEAL POX
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CAPRIPOX
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PIG POX
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MYXOMATOSIS
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FOWL POX
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Summary

• Poxviruses can survive for years in dust.
• They are transferred via skin abrasions and
  insects can be mechanical vectors eg for myxoma
  or swine pox. Many are zoonotic infections eg
  orf and cowpox.
• Most cause skin papules and scab after a few
  weeks but some cause a generalised infection eg
  (sheep pox).
• Traditional vaccines exist for orf, mxyomatosis
  and for sheep pox
• Recombinant vaccines have developed but have
  zoonotic potential, the fox-rabies vaccine
  worked.