Available and Ongoing Clinical Trials for Parkinson

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Available and Ongoing Clinical Trialsfor
Parkinsons Disease Patients
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EARLY PD

• Rasagiline may slow progression of PD
• In a preliminary delayed start study those who
  took rasagiline from the beginning did better
  than those who started it after 6 months
• Istradefylline may improve PD symptoms without
  causing dyskinesia

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EARLY PD

• STRIDE and FIRST STEP evaluate Stalevo vs.
  Sinemet with regard to
• Does Stalevo improve PD more than Sinemet?
• Does Stalevo cause less dyskinesia?
• Does Stalevo lower homocysteine? Elevations of
  homocysteine may cause strokes and be associated
  with dementia
• CoQ10
• May slow progression of disease
• Stabilizes energy production in cells

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MODERATE PD

• Glutathione antioxidant
• May improve symptoms
• May slow progression
• Eye Safety Study
• Tests eyesight while taking Parkinson Disease
  medications

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ADVANCED PD

• Istradefylline for patients with fluctuations
• Spheramine transplantation of retinal cells
• These cells make levodopa and serve as levodopa
  pumps in the brain
• for pts with moderate severe symptoms in the
  morning before taking medication
• Sarizotan for dyskinesia

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OTHER

• Fatigue Study
• Try to understand and treat potential causes of
  fatigue in PD
• Psychosis Study
• Evaluating the use of Melperone (an
  antipsychotic) in PD patients with psychosis
• SPECT scan studies
• Develop a scan as a diagnostic tool to discern
  between Parkinsonian and non-Parkinsonian tremor

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If interested in clinical trials, please call

• 813-844-4455
• or
• 813-974-5909