OCULAR DRUG DELIVERY SYSTEM

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OCULAR DRUG DELIVERY SYSTEM
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We shall discuss

• Introduction
• Anatomy of eye
• Drug penetration barrier
• Conventional ocular formulation
• Recent Controlled Release Ocular Delivery
• - Approaches
• - Formulations
• - Ocular Delivery Device
• References

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Introduction to Ocular Drug Delivery

• Treatment for?
• Goal?
• Drugs used

4
Anatomy of eye
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Drug Penetration Barrier in Cul-de- sac
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Conventional Ocular Formulations

• Solutions
• Suspensions
• Emulsions
• Ointments
• Gels
• Erodible inserts
• Non-erodible inserts

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Recent Control Release Ocular Delivery

• Major Approaches

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Recent Control Release Ocular Delivery

• Formulation
• Polymeric solutions
• Phase transition systems
• Mucoadhesive/bioadhesive dosage form
• Collagen shields
• Pseudolatices
• Micro emulsions.
• Ion exchange resin suspension.

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Recent Control Release Ocular Delivery

• Formulation
• Polymeric solutions

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Recent Control Release Ocular Delivery

• Formulation
• Phase transition systems

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Recent Control Release Ocular Delivery

• Formulation
• In situ Gels
• Thermo reversible gel
• pH induced Gel
• Ion induced Gel
• Dilution induced gel

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Recent Control Release Ocular Delivery

• Formulation
• Mucoadhesive/bioadhesive dosage form

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Recent Control Release Ocular Delivery

• Formulation
• Collagen shields

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Recent Control Release Ocular Delivery

• Formulation
• Pseudolatices

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Recent Control Release Ocular Delivery

• Formulation
• Micro emulsions.

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Recent Control Release Ocular Delivery

• Formulation
• Ion exchange resin suspension.

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Matrix type
• Hydrophillic soft contact lenses.
• Soluble ocular inserts.
• Scleral bulking materials
• Capsule type
• Ocusert
• Implantable silicone rubber devices.
• Particulate System
• Microspheres and Nanosphers
• Vesicular system
• Liposomes
• Niosomes
• Pharmacosomes
• Discosomes
• Other delivery devices
• Ocufit and lacrisert
• Minidisk ocular Therapeutic systems.
• The New ophthalmic delivery systems (NODS)

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Matrix type
• Hydrophillic soft contact lenses.

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Matrix type
• Soluble ocular inserts.
• (1) Poly(viny alcohol) insert (PVAI)
• (2) Soluble Ophthalmic Drug Inserts
• (3) Polypeptide Device

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Matrix type
• Scleral bulking materials

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Capsule type
• Ocusert

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Capsule type
• Implantable silicone rubber devices.

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Particulate System
• Microspheres and Nanospheres

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Vesicular system
• Liposomes

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Vesicular system
• Pharmacosomes

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Vesicular system
• Discosomes

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Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Other delivery devices
• Ocufit and lacrisert

28
Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Other delivery devices
• Minidisk ocular Therapeutic systems

29
Recent Control Release Ocular Delivery

• Ocular Delivery Devices
• Other delivery devices
• The New ophthalmic delivery systems (NODS)

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References

• S.P.Vyas,Roop K.Khar. Controlled drug delivery
  (Concepts Advances) First Edition 2002,383-411.
• R.Gurny,S.EinmachlM.Zignani,E.Varesio,J.Heller,J.L
  .Veathey,C.Tabatabay. Concomitant and controlled
  release of dexamethasone and 5-Flourouracil form
  poly(ortho ester),Inter.J. Pharm.185(1999),189-198
  .
• M.S.Nagarsankar,Vaishali y.Londhe,G.D.Nadkarni.
  Preparation Evaluation of liposomal formulations
  of tropicamide for ocular delivery
  ,Inter.J.Pharm.190(1999)63-71.
• Jagdish balsubhramanium,Shrikani jayant, Kumar
  Pandit, Invitro in vivo evaluation of the
  Gelrite Gellan gum based ocular delivery system
  for indomethacin,Acta Pharm 53(2003),251-261.
• C.S.Cho,K.y.cho, T.W.chang, B.C.kim,M.K.kim,J.H.L
  ee,W.R.Wee.Release of ciproflaxacin form
  poloxamer-graft-hyaluronic acid hydrogels in
  vitro,Inter.J.Pharm.260(2003),83-91.
• Marie Sherlund. Insitu gelling drug delivery
  systems for periodontal Anaesthesia.Ph.D. Thesis
  ,Acta university .(2002)
• Michelle C. Callegan, Jeffery A. Hobden, Richard
  J. Ocallaghan, James M. Hill. Ocular drug
  delivery A comparision of transcorneal
  iontophoresis to corneal collagen
  shields,Inter.J.Pharm.123(1995)173-179.
• Amelle Bochot, Elias Fattal, Jean Louis
  Grossiord, Francis Paisicax,Patrick Coavrear
  .Characterization of a new ocular delivery system
  based on a dispersion of liposomes in a
  thermosensitive gel,Inter.J. Pharm.162(1998),119-1
  27.

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References

• Amaranth Maitra, Ajay Kumar Gupta, Sumit madan,
  D.K.majandar.Ketorolac entrapped in Polymeric
  Micelles,Inter.J.Pharm,209(2000),1-14.
• A.Radomska,R.Dobrucki. The use of some
  ingredients for microemulsion preparation
  containing retinol and its esters,Inter.J.Pharm.19
  6(2000),131-134.
• Maria J. Alanco,Pilar calvo, Jose L. Vila-Jato.
  Evaluation of cationic polymer coated
  nanocapsules as ocular drug carriers,Inter.J.Pharm
  ,153(1997),41-50.
• M.A.Eger,F.Gamisans, F.Lacoulonche, A.chaavet,
  M.Espina, M.L.Garcia.Flurbiprofen-loaded
  nanospheres Analysis of the matrix structure by
  thermal methods,Inter.J.Pharm,179(1999)37-48.
• J.Kreuter,K.Langer, E.Matshceler,G.Lambrecht,
  D.Mayer, G. Troschau,F.Styeneker.Methyl
  methacrylate sulfopropyl methacrylate copolymer
  nanoparticles for drug delivery.Inter.J.Pharm,158(
  1997)219-231.
• Samuel H. Yalkowsky, Yang chi Lee. Ocular
  devices for the controlled systemic delivery of
  insulin In vitro in vivo dissolution ,
  Inter.J.Pharm,181(1999),71-77.
• Samuel H. Yalkowsky, yag-chilee, Jeffrey W.
  millard. Gera K. Negvesky, Salim I.
  Butrai.Formulation and in vivo evaluation of
  ocular insert containing phenylephrine and
  tropicamide.Inter.J.Pharm,182(1999),121-126.
• Jing Xu,Jeffrey J. Heys, Victor h. Barocas, and
  Theodare W. Randolph.Permeability and diffusion
  in vitreus humar Implications for Drug
  Delivery.Pharm.Res. Vol.17,No.6,2000,664-669.

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References

• Encyclopedia of Pharmaceutical Technology Vol
  11 ocular drug delivery Pg 43-76.
• http//www.oftalmo.com/seo/2003/02feb03/02.htm
• http//www.uic.edu/com/eye/LearningAboutVision/Eye
  Facts/CollagenCornealShields.shtml
• http//www.ncbi.nlm.nih.gov
• http//www.revophth.com/archive/newsletter/ro_1213
  04.htm
• http//www.merck.com/product/usa/pi_circulars/l/la
  crisert/lacrisert_uspc_pi.pdf

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