Enzymes 2nd Year Dentistry

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Enzymes 2nd Year Dentistry

• By
• Eman Mokbel Alissa, Ph.D.

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Lecture (1) Lecture Content

• Enzyme Definition
• Enzymes vs. biological catalysts
• Enzyme Nomenclature
• Recommended name and IUBMB system
• Enzyme Classification
• Simple and complex enzymes

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Lecture (2) Lecture Content

• Coenzymes
• Properties of enzymes
• Catalytic efficiency
• Location within cell
• Enzyme active site
• Specificity
• 2 hypothesis of enzyme specificity

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Lecture (3) Lecture Content

• Mechanism of enzyme action
• Mechanism of enzyme catalysis
• The Enzyme Substrate Complex
• Factors Affecting Reaction Velocity

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Lecture (4) Lecture Content

• Enzymes Kinetics
• Michaelis-Menten equation
• Linweaver-plot
• Types of Enzyme Specificity
• Mechanisms of enzyme catalysis

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Lecture (5) Lecture Content

• Enzymes Inhibitors
• Reversible and irreversible
• Competitive and uncompetitive
• Medical relevance of enzyme Inhibitors
• Antibiotics
• Enzymes Clinical Application

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Lecture (6) Lecture Content

• Common Terminology
• Allosteric enzymes
• Allosterism vs. cooperativity
• Allosteric Enzymes Kinetics
• Feed back inhibition
• Homotropic and Heterotropic effectors
• Enzyme Activity Regulation
• Induction and repression
• Covalent modification
• Compartmentalization

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Lecture (7) Lecture Content

• Enzyme measurements
• Plasma Enzymes
• Serum enzymes in Diagnosis
• Isoenzymes