Dr. Frederick Banting

1
Dr. Frederick Banting Charles Best

• 1921 discovered insulin using dogs
• 1922 14-yr-old boy with diabetes, near death,
  first person to receive insulin
• 1923 Nobel prize

2
Laminitis Nutritional Management

• Pasture water-soluble CHO
• Glucose, fructose, sucrose, fructans
• May cause laminitis
• Fructans suggested to disturb normal fermentation
  in hindgut
• But, no direct link between laminitis specific
  pasture CHO

3
Fructans

• Polymer of fructose molecules
• 3 types inulin, levan, mixed
• Storage CHO in grasses (C3)
• Tall fescue, crested wheatgrass, timothy,
  orchardgrass, bluegrass, bromegrass, wheat, oats,
  barley

4
Fructans

• Stem base, lower stem, rhizomes
• Allow grasses to be tolerant to freezing

5
Fructans

• Not digested in equine small intestine
• Pass into hindgut
• Fermented by microbes (Gram )
• Factor(s) released that trigger laminitis????

6
Laminitis Grass Founder

• Limited info on how much water-soluble CHO would
  cause problems
• Environmental conditions affect amount in forage
• Highest spring, lowest summer, intermediate
  fall

7
Laminitis Grass Founder

• Fructans increase when
• Bright sunshine during day, with cool nights
• Coincides with increased incidence of grass
  founder

8
Laminitis Grass Founder

• Diurnal variation
• Rise in am, peak in afternoon, decline overnight
• Grazing in afternoon compared to am or night
  consume more (2-4 x) water-soluble CHO