Gametogenesis in the adult hermaphrodite of C. elegans

1
Gametogenesis in the adult hermaphrodite of C.
elegans
2
Chromosome structures in the gonad of the adult
hermaphrodite
3
0-8h II (early embryogenesis) III (diakinesis
oocyte) 8-24h III IV V VI (diplotene to
pachytene nuclei)
4
(0- 8 h) (8 22lt h)
Egg hatchability in the wild-type hermaphrodite
after X-ray irradiation
5
Egg hatchability in the wild-type hermaphrodite
after heavy ions and UV irradiation
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Requirement of Ce-rdh-1 Ce-atl-1 genes for
ds-break repair system
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Requirement of Ce-atl-1 gene for UV-damage repair
system
8
CED3 apoptosis system is dispensable for ds-break
repair system in meiotic cells.
9

• Conclusion
• Meiotic pachytene nuclei were hyper-resistant to
  X-ray, 12C, and 18Ar-ion beam irradiation.
• It suggests that general recombination activity
  during meiosis can effectively repair ds-breaks
  and gaps by X-ray, 12C, and 18Ar-ion beam
  irradiation.
• A checkpoint kinase Ce-atl-1 (ATM/ATR like 1) was
  also involved in repair for X-ray and UV damages
  of mitotic and meiotic cells.