Taichung, Taiwan ??,??

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Taichung, Taiwan ??,?? March 26,
2004 ?????? The Miracle of Antioxidants ???????
Lifestyle and Health ?????????? HOW TO LIVE IN A
TOXIC WORLD
????? Prof. Lester Packer
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?????? Free Radical Sources

• ?? Smog(nitrogen dioxide, ozone)
• ?? smoke
• ??????? Environmental Chemicals
• ??? Halogenated Hydrocarbons
• ??? Heavy Metals
• ????? Alcoholic Beverages
• ???? Anti-Cancer Drugs
• ???? strenuous exercise

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Oxidative Stress
????
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???????? Clinical conditions and free radicals
Cataractogenesis Retinal damage Macular
degeneration
Sunburn Burns Dermatitis Psoriasis Scleroderma
Renal graft Glomerulonephritis
Hepatitis Endotoxin liver injury Ulcerative
colitis Ischemic bowel
? Eye
? Kidney
?? Skin
??? GI
Heart attack
??? Free Radicals
? Heart
?? Teeth
Periodontitis
?? Joints
Rheumatoid arthritis
?? Vessels
? Lung
????Multiorgan failure
Asthma ARDS Hyperoxia Cystic fibrosis
? Brain
Vasospasm Atherosclerosis
Trauma Stroke Epilepsy Alzheimers Parkinsons Neu
rotoxins Dementia
Radiation Aging Cancer Inflammatory-immune
injury Ischemia-reperfusion injury Diabetes
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???????????????? Human Diseases Avoidable by a
Change in Lifestyle
??? Percent avoidable
100
80
60
40
20
0
?? Stroke
????? Coronary disease
?????? Diabetes Type 2
??? Colon cancer
-
Walter Willett Science 296, 695-698 2002
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??????????????? ?????? Fruits and Vegetables are
Sources of Antioxidants and Minerals Needed for
Antioxidant Enzymes

• ???C Vitamin C
• ???E Vitamin E
• ????? Carotenoids
• ??? Polyphenols (Flavonoids)
• ???,??? Q10,???????
• Lipoic Acid, Co-enzyme Q, other Biofactors
• ?,?,?,?,? Selenium, Copper, Zinc, Manganese, Iron

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Dendrobium pompadour This orchid contains
flavonoids and anthocyanins.

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100,000????????? Death rates per 100 000
population for heart disease By sex, ages 45-65,
in 27 countries, 1985
????? Other Heart Disease
??? Coronary Heart Disease
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?????????? Cross Cultural Study of Heart Disease
Mortality
???
??
????
??
??
???
????
??
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?????? European Populations
88,000????? 88,000 Nurses Study
Northern
Southern
???????? Age Adjusted Relative Risk
100,000?????? Average of Deaths/100,000 people
1.0
99
0.59
366
19-20µM
27-28µM
2.8
208
Vitamin E, Median Intake (IU per Day) for at
least 2 years
Vitamin E, a-tocopherol Median of Standardized
Plasma Values
M.J. Stampfer, et al., N Engl J Med
3281445(1993)
Gey, F., et al, Am J Clin Nutr (1990)
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??4
??
??3
??2
??1
??
Milgram, MW, et al Neurobiology of Aging 2002
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????????????????????? Antioxidant supplemented
diets prevent age associated cognitive
dysfunction in old dogs
Errors to Criterion (mean)
200
Antioxidants
Control
150
100
50
0
?? - 1
?? - 4
?? - 2
?? - 3
Milgram, N.W., Zicker, S.C., Head, E.,
Muggenburg, B.A., Murphey, H., Ikeda-Douglas, C.,
and Cotman, C.W., Neurobiology of Aging, 2002
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??--???????? ???????
24?????????? (MED)??????UV-B ??????????
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0.75 SSUV?????????????E???? A single dose of 0.75
SSUV depletes Vitamin E, a- tocopherol in human
stratum corneum
???E
a-tocopherol ( pmol)
n 6
Single individual
Upper arm of six volunteers was sequentially tape
stripped after exposure to 0.75 SSUV (left arm,
0.75 MED). The contralateral site served as a
control (right arm, control). Significant
differences between corresponding SC layers in
controls and treated sites are indicated by
asterisks. , p lt0.001.
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????? Antioxidant Network
????? Carotenoids
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????Lycopene
?-???? Beta-carotene
??? Lutein
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Resonance Raman spectroscopy measures carotenoids
in the skin
???????????????
Werner Gellermann Laboratory
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???????????Population Distribution of Skin
Carotenoids
120
Average American
th
99
Mean 19,072
th
95
th
90
SD 8,828
th
75
1,375 Subjects
100
th
50
th
25
th
10
80
th
5
Percentile Rankings
st
1
1st 4,500
5th 8,500
Frequency
60
10th 10,500
25th 13,500
50th 17,500
75th 22,500
40
90th 30,500
95th 36,500
99th 48,000
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0
1000
4000
7000
61000
64000
67000
70000
73000
76000
79000
10000
13000
16000
19000
22000
25000
28000
31000
34000
37000
40000
43000
46000
49000
52000
55000
58000
Biophotonic Scanner measurement
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???????????????????????????Study Demonstrating a
High Correlation Between Human Serum and Skin
Carotenoids
Toata Skin,Raman Intensity
60,000
40,000
20,000
r 0.78 p lt 0.001
0
0.0
1.0
2.0
3.0
4.0
g/ml)
m
Total Serum Carotenoids (
Measurements Serum HPLC, Skin Biophotonic
Scanner
Courtesy Carsten Smidt
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???E???????????????????? Vitamin E and
Carotenoids in skin reflects the antioxidant
status in the human body
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• ?????????
• Antioxidants destroy free radicals
• ???????? Antioxidants work together
• ??????? The Antioxidant Defense System
• ???????????????????????????
• continuous supply of antioxidants and
  micronutrients from the diet and/or supplements
  is required
• ????,???????
• Slows aging, improves Healthy Aging

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