Gametocytes fuse to form

1
Sporozoites enter The liver
Detoxified by heme polymerizase forming hemozoin
Mosquito infects human with plasmodium
sporozoites upon biting
Sporozoites reproduce asexually and enter blood
stream
Plasmodium multiply
Gametocytes fuse to form sporozoites in mosquito
Free heme is toxic In high concentrations
Plasmodium (re)enters Red Blood Cells
Gametes enter a new mosquito when it bites
infected human
Plasmodium cannot breakdown heme
Red blood cells lyse releasing merozoytes
Plasmodium digest Hemoglobin in the food vacuole
Some merozoites Develop into male female
gametocytes
Plasmodium reproduces asexually in red blood
cells
Heme from hemoglobin is released into the vacuole