Your gift or donation is tax deductible

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Your gift or donation is tax deductible
About Frontiers in Bioscience Research Institute
Frontiers in Bioscience research institute in
aging and cancer was launched in 2011. The
mission of the institute is to find cure for
cancer, identify pathways for reversal of aging
and to provide a forum for public education and
fund raising. Scientists at the institute will
examine innovative non-radiotherapeutic and
non-chemotherapeutic approaches for treatment of
all solid cancers. New ideas that can reverse the
age induced damage to DNA and cell organelles
will also be pursued. The institute will also
launch a rejuvenation clinic for slowing down the
speed of aging. Interested individuals can
contact the institute for further information.
The institute will be funded through tax
deductible donations, fund raising events, and
educational programs. Various galleries
participate in fund raising through providing
artworks that are gifted to philanthropic donors.
Support us Frontiers in Bioscience Research
Institute 16471 Scientific Way Irvine, CA
92618 www.bioscience.org/ri.htm fbs_at_bioscience.
org
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Siamak Tabibzadeh obtained his MD degree in
1977, was board certified in Pathology in 1982
and became assistant professor in Pathology in
1983. He was promoted to the rank of associate
professor and then to the position of full
professor at University of South Florida in early
1990s and obtained full professor position at
Stony Brook University in 2000 and at UCI in
2011. Dr Tabibzadeh has authored over 100
publications, has six patents and cloned one of
the human genes (EBAF/LEFTY) in 1997. Dr
Tabibzadeh established Frontiers in Bioscience
journal in 1996 which is now recognized as one of
the top 50 biology journals in the world. Dr
Tabibzadeh founded the Frontiers in Bioscience
Research Institute in Aging and Cancer in 2011 in
pursuit of finding a cancer cure and pathway(s)
to the reversal of aging. Dr Tabibzadeh is
committed to making the research institute to be
one of the pre-eminent research centers for
excellence in science. Selected
Publications Satyawaroop PG, Tabibzadeh
S Extracellular matrix and the patterns of
differentiation of human endometrial carcinomas
In vitro and In vivo. Cancer Res 515661- 5666,
1991
Siamak Tabibzadeh, MD President, Full
professor Frontiers in Bioscience Research
Institute in Aging and Cancer tabibzadeh_at_bioscienc
e.org
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JM Mason, Hao-Peng Xu, Srinivasa. K. Rao, Andrew
Leask, M Barcia, Jidong Shan, Robert Stephenson,
S Tabibzadeh Lefty contributes to the remodeling
of extracellular matrix by inhibition of CTGF and
collagen mRNA expression and increased
proteolytic activity in a fibrosarcoma model. J
Biol Chem 4, 407-415, 2002 http//www.jbc.org/cgi
/reprint/277/1/407.pdf Tabibzadeh
S Homeostasis of Extracellular Matrix By TGF-BETA
and LEFTY Front Biosci 7, d1231-1246, 2002 Li
J, Kokkola R, Tabibzadeh S, Yang R, Ochani M,
Qiang X, Harris HE, Czura CJ, Wang H, Ulloa L,
Wang H, Warren HS, Moldawer LL, Fink MP,
Andersson U, Tracey KJ, Yang H. Structural basis
for the proinflammatory cytokine activity of high
mobility group box 1. Mol Med.
Jan-Feb9(1-2)37-45. 2003 Tabibzadeh S,
Hemmati-Brivanlou A LEFTY at the crossroad of
'stemness' and differentiative events. Stem
Cells. 24, 1998-2006, 2006 doi10.1634/stemcells.2
006-0075 PMid16728558
R Kothapalli, I Buyuksal, S-Q Wu, N Chegini, S
Tabibzadeh Detection of EBAF, a novel human gene
of the TGF-beta superfamily association of gene
expression with endometrial bleeding. J Clin
Invest 99, 2342-2350, 1997 http//www.jci.org/cgi
/reprint/99/10/2342.pdf PubMed No 9153275
Tabibzadeh S, Mason J, Cai Y, Wendy S, Murray
MJ, Lessey B Dysregulated expression of EBAF, an
occult and novel molecular defect in the
endometria of patients with infertility. J Clin
Endocrinol Metab 85, 2526-2536, 2000
http//jcem.endojournals.org/cgi/reprint/85/7/252
6.pdf doi10.1210/jc.85.7.2526 Ulloa L,
Creemers JW, Roy S, Liu S, Mason J, Tabibzadeh
S. Lefty proteins exhibit unique processing, and
activate the MAP kinase pathway. J Biol Chem
276, 21387-21396 (2001) http//www.jbc.org/cgi/re
print/M006933200v1.pdf doi10.1074/jbc.M006933200
PMid11278322 Ulloa L, Tabibzadeh S Lefty
inhibits R-Smad phosphorylation induced by
activated TGF-beta receptor J Biol Chem 276,
21397-21404 (2001) http//www.jbc.org/cgi/reprint
/M010783200v1.pdf doi10.1074/jbc.M010783200 PMid
11278746
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Gaetan Mayer, Josee Hamelin, Marie-Claude
Asselin, Antonella Pasquato, Edwidge
Marcinkiewicz, Meiyi Tang, Siamak Tabibzadeh, and
Nabil G. Seidah The regulated cell-surface
zymogen activation of the proprotein convertase
PC5A directs the processing of its secretory
substrates. J Biol Chem 283(4), 2373-2384.
2008 doi10.1074/jbc.M708763200
PMid18039650 Devendra G Naidu, Meiyi Tang,
Siamak Tabibzadeh Lefty peptides, derived by
MMP2 cleavage, act as a new class of gelatinase A
inhibitor. Front Biosci 13, 7193-7201, 2008
Meiyi Tang, Devendra Naidu, Patrick Hearing,
Stuart Handwerger, and Siamak Tabibzadeh LEFTY,
a member of the TGF-beta superfamily, inhibits
uterine stromal cell differentiation. A novel
autocrine role. Endocrinology. 151, 1320-1330,
2010

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Daniel Tabibzadeh, a graduate of Stony Brook
University, obtained his bachelor