Familial Hypercholesterolemia

1
(No Transcript)
2
(No Transcript)
3
(No Transcript)
4
(No Transcript)
5
Familial Hypercholesterolemia Genetic disease
from a mutation of the LDL receptor (doesnt
remove LDL from circulation)
6
(No Transcript)
7
ATP used to Initiate ß-oxidation
8
(No Transcript)
9
(No Transcript)
10
Page 746
11
NADPH
12
(No Transcript)
13
(No Transcript)
14
(No Transcript)
15
Cascade for Biosynthesis of Eicosanoids
2
16
Biosynthesis of Eicosanoids
Arachadonic Acid (?-6) Cleaved from phospholipids
via a phospholipase
Cyclooxygenases
Prostaglandins (thromboxanes)
Leukotrienes
3
17
COX catalyzed reaction
4
18
COX Inhibitors
5
19
COX Inhibitors
5
20
Aspirin Mode of Action
6