The Isotonix

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The Isotonix Advantage
Mark Lange, Ph.D. Director, Quality
Control Market America
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OVERVIEW

• Understanding Your Digestive System
• Transporting Nutrients into Cells
• The Isotonix Delivery System
• Isotonix Advantage 1,2,3..

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STOMACH

• Secretes 5 substances mainly
• Water diluent
• Chloride ions
• Hydrogen ions
• Pepsin proteolytic enzyme (proteins)
• Intrinsic factor vitamin B-12 binding protein
  released by parietal cells

Hydrochloric acid HCl pH 1.0 2.8
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Isotonix Advantage 1

• Nutrients are not exposed to acidic environment
  of stomach, where they would otherwise degrade.
• Customer money is not wasted.

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Isotonix Advantage 2

• Reduced delivery time.
• Example B vitamins for energy
• Minutes to uptake not hours

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SMALL INTESTINE

• ACIDIC FOOD SOLUTION stimulates pancreas to
  release numerous digestive enzymes in a sodium
  bicarbonate solution
• NEUTRALIZATION pH of food solution changed from
  acidic to nearly neutral

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SMALL INTESTINE

• BILE is a product of the liver, collected in the
  gall bladder, and secreted onto the food
  solution.
• Contains surfactants that disperse fat.
• Lipases act on triglycerides, releasing fatty
  acids.

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Isotonix Advantage 3

• Carbon dioxide created by the effervescent
  reaction reduces the thickness and viscosity of
  the mucus layer of the intestinal tract,
  promoting absorption into the cells.
• Pharm. Res. 1998, vol 15, pp 925-930.
  Mechanistic studies on effervescent-induced
  permeability enhancement.

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FOLDS IN THE SMALL INTESTINE
Villi
Mucosa
Sub - Mucosa
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The Cell Membrane

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Cell Membrane Barriers

• Lipid bi-layers are impermeable to most essential
  molecules and ions.
• Oxygen, Water, Carbon Dioxide can freely pass.
• Many nutrients cannot freely pass.

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Movement through Differences in Concentration

• Diffusion is moving molecules from a region of
  higher concentration to a region of lower
  concentration.

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Simple Diffusion
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Higher concentrations move nutrients into cells

Membrane (lipid bi-layer)

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Isotonix Advantage 4

• Favorable concentration gradient for absorption
  of some nutrients. Example Calcium/Magnesium
• Nutrients are delivered to the small intestine in
  a concentrated solution.

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Facilitated Diffusion

• Takes place through channels embedded in the
  membrane.
• Example Fructose moved into cell by facilitated
  diffusion.

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Active Transport

• Pumping of molecules or ions through a membrane
  into a region of higher concentration. It
  requires a trans-membrane protein and energy
  input.
• Example Amino Acids, ATP, Sodium, Potassium
  moved into cell by Active Transport.

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SMALL INTESTINE

• Absorption of nutrients occurs throughout entire
  length of small intestine (90 95 efficient)
• Calcium absorption occurs as late as ileo-cecal
  juncture (appendix) ? transport into cells via
  calcium channels
• Under neutral pH, intrinsic factor binds to
  vitamin B-12 to form a complex

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SMALL INTESTINE

• Intrinsic factor/vitamin B-12 complex binds to
  receptors (specialized docking structures) on
  intestinal membranes
• Last 1/3rd of small intestine is main absorptive
  site

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COLON

• Most nutrients will have been absorbed by the
  time they reach the large intestine an
  additional 3-5 possible.
• Major functions of colon
• Site of bacterial cell growth and residence
• An estimated 300-400 species or strains of
  bacteria continue digestion of waste products
• Regulates water in body
• Some vitamins produced in low amounts by bacteria
  and absorbed

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COLON

• Bacteria adjust the pH of the colon into the
  acidic range prevents overgrowth of harmful
  bacteria.
• Continued growth of friendly bacteria help
  maintain healthy balance.

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What does isotonic mean?

• ISO SAME
• TONIC Tension or Pressure
• An Isotonic Cell is a Happy Cell.

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Cells act like little bags of salty water..

• The movement of water in and out of a cell is
  called Osmosis.
• Cells want the same concentration of dissolved
  particles (salt) on both sides of the membrane.

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HYPOTONIC (WATER GOING IN)
HYPERTONIC (WATER GOING OUT)
ISOTONIC (NORMAL)
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Isotonix Advantage 5

• Isotonic solutions are the optimal delivery
  system.
• Isotonix products work with not against
  normal body physiology.

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Composition of Isotonix Delivery System

• Active ingredients vitamins, minerals,
  oligomeric proanthocyanidins (OPC), flavonoids,
  coenzyme Q10, etc.
• Base ingredients fructose, glucose, citric acid,
  malic acid, calcium sulfate, maltodextrin,
  silica, potassium bicarbonate

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Composition of Isotonix Delivery System

• Glucose and fructose
• Sweet-tasting simple sugars
• Add significant osmotic pressure
• Caloric value ( 8 cal/serving)
• Fructose principle sugar in formula scores 20
  out of 100 on glycemic index (i.e., relatively
  low value)

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Composition of Isotonix Delivery System

• Citric acid and malic acid
• Adjust pH to acid range (about 3.5 5.0)
• Adjust taste to citrus flavor
• Minor osmotic pressure adjustment

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Composition of Isotonix Delivery System

• Calcium sulfate
• Desiccant (takes up moisture in powder) /
  free-flow agent
• Minor osmotic pressure adjustment
• Minor nutritive value

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Composition of Isotonix Delivery System

• Maltodextrin
• Glucose polymer has minor caloric value
• Powder bulking agent
• Prevents citric acid from reacting with potassium
  bicarbonate and water
• Thickening and suspending agent in solution

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Composition of Isotonix Delivery System

• Potassium bicarbonate
• Potassium and bicarbonate ions have significant
  osmotic pressure
• Helps adjust and buffer pH
• Release of CO2 stirs liquid

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Isotonix Advantage 6

• Isotonix offers an alternative to pills.
• Survey shows 40 of American adults have
  experienced difficulty swallowing pills
• The survey of 679 adults (513 ages 18-64, 166 age
  65 and older) was funded by the US affiliate of
  Germany's Schwarz Pharma.

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Isotonix Advantage 7

• People with stomach and esophageal challenges
  benefit from Isotonix delivery.
• Acid reflux sufferers
• Bariatric patients
• Hiatal Hernia (stomach protrudes up through
  diaphragm)
• People who have trouble swallowing
• Elderly (reduced acid production)

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Conclusion

• Isotonix product line offers customers a wide
  selection of nutrient combinations with the
  advantages of isotonic delivery.
• Isotonix is the logical choice of those seeking
  fast and optimal nutrient uptake.