133Xe ?????????? ventilation scintigraphy

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133Xe ?????????? ventilation scintigraphy 133Xe
(????????) ??? 5.3? 81keV LEGP 81mKr (???13?)
??????????????? ???????????185MBq????????? ???????
????????????????? ???????????????(washout)? ?????
?????????????? ?????? ????????(COPD chronic
obstructive pulmonary disease) ?
?????? ??????????
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??? Emphysema 133Xe scintigraphy ??????????????(?
??????? ???????)????????????
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201Tl ????
201Tl ???? 201Tl ??K(????)???????? ??????????????
???? Na-K????K??????????? ????????????????? ??Tl??
???????????? ??????Na-K????????Tl? ???????????10??
????? 201Tl???????????(73??) ???????????????? 24?
??????????????? (4?)?????????RI???
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111InCl Bone marrow scintigraphy ????????? 111In
171 keV, 245 keV MEGP ????? 111
MBq?? 4872?????? 111In??Fe?????????? ????????????
( ?? ??????????)????? ????(????)?????? (?????????
?????) ???????????
???
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99mTcO4-(????????) ????????????? 185 MBq ???
?????????????????????? ?????????????????? 5, 10,
20, 30 ?????? 99mTcO4-?????? ??????? ?????????
??????? ???????? ?????? ??????????? ???????????
????????? ?????????
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99mTc-HSA ( ????????? Human serum albumin
) 99mTc-RBC (?????) ?????????185MBq ??? 1020
?????????? ?????? ( 99mTc-HSA ???????????)
99mTc-HSA ???????????????? ?????????????????? ????
???????? ??????????(???????)???? 99mTc-RBC????????
?????? (???????????????????? ?(?????)?????)?
30min
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99mTc-RBC ????????????
??????????? 99mTc-RBC?????????? 185MBq????5,10,20,
30?? ???????????????? ????????????? ???????24?????
???????????
10sec/F
30min 2.5hrs 7hrs
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???????????

• 131I-MIBG(131I-meta-iodobenzil-guanidine)
• 131I 364 keV HEGP????? ??? 8?
• 131I ??????????????????????
• 20MBq????2?????????????????
• ????????????
• MIBG???????????????????????
• (?????????????????)?
• ???????????(?????(10???)?
• ?????????????????????????)?
• ?????????????????????????
• 131I ????????????????????????

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???????? Pheochromocytoma
131I-MIBG 20MBq
Rt ANT Lt POST
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??????? ?????? Malignant Pheochromocytoma
Multiple bone metastases
131I-MIBG 16GBq ??????
ANT POST
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123I-MIBG ?????????????????? 123I 159keV LEHR
??? 123I ??????? 111MBq??20????Early
??????SPECT?? ??4?????Delayed????????SPECT?? 13
1I-MIBG ???????????????? 131I 364 keV
HEGP????? ??? 8? 131I ??????????????????????
20MBq????2????????????????? ???????????? ???????
?????? 123I-MIBG ?????? ??????????
??????????????????????????????123I-MIBG????????? (
?????????????????? ???????)
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123I-MIBG ?????131I-MIBG?????????
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123I-IMP Brain SPECT ????????(Lt. MCA stenosis)
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123I-IMP (N-isopropyl iodo- amphetamine ) 123I
159keV LEHR ??? 123I ??????? ??? 111
MBq ?????????????????????????? ??????????????????
???????? ?????????????????????????? ?????????????
1?????????? 10???????????????????? ??20???SPECT??2
0??? ???????????(ARG?)??????????? ??????
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123I-IMP Brain SPECT ??? ??? (CBF) ??
(Cerebral Blood Flow) ???????????????????
??????? ??????SPECT????????????????? PET??????????
????????????
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???????????????? (????)?? ????????????????????????
??????? ??????????????????? ??????????????????????
????????
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PET ?????? ( CBF ) ????
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PET??? PET????????????????????
PET????????????????????? ???????????????????????
????????PET??????????? (1???? 10?????)????????????
???????? ????? SPECT?????????????????????? ??????
???????????????????? ???PET???????????????????? ??
????????? (ARG? Auto Radiography) ???????
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ARG????? ??????????????????????????? IMP?????????
??1??????????? ????????????????? ????????????????
?????????????? ?????????????????????????????? ???
?????????????????????????? ?? (?????????)?????????
????????? ?????(???????????????????IMP???) ???????
?????????????????? ?????????????(???????)????????
?? ?????10???1??????????????
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10???1?????????????????????????? ?????????????????
????? ?????????????????????????????? (???? 0.7
?????)????????????
123I-IMP ?????????
123I-IMP ??????
IMP????????????? ??????????????? 10???????????? ??
????10??????? ???????????? ?
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?????????? IMP??????????? IMP???????????1?????????
?? ????????????????? ???????????????1????
25???? ??????SPECT????????????????????? ????????
????? (???????)?????????? ????? 20 ???? 40 ?????
20???SPECT??? 1???? Chang???? 30??????????????? S
PECT?????????????????????????? 123I
?????????????SPECT???20?????? ???SPECT????????(Cha
ng??)? SPECT?????(count)?????(Bq/ml)?????????? (??
??????????)? (??????1???????)
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Chang ? ?????????? ???? ???????µ???????????? 99mT
c???µ? 0.10??0.12 /cm ???????
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???????? ???????? (???? Cp (t) )?? ???????? ??????
? X (t) ? ?????
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??????1???????????????????? ??????????????????????
???????? ????????????????????????????? ???????????
??????????????? ????? ??????????? (ARG?)
???? ???? Cp(t) ????????? X(t)
?????? ??????????????IMP ? 3 ???????????? ????????
? ????????????(????????)?????? (Cp) (????????(plas
ma)?????????????)? ????????? (X1)??????????????
(X2)? 3??????????????????????
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3 Compartment model analysis ( case k4 0 )
Cp(t)
X(t) ( X1(t) X2(t) )
K1 (ml/min/g)
k3
X2(t)
X1(t)
k40
k2 (1/min)
Artery
Tissue
d X1(t)
K1 Cp(t) - ( k2 k3 ) X1(t)
d t
d X2(t)
k3 X1(t)
d t
( )
2
k3
K1
k2
Ki K1
Vd
k2 k3
k2
k2 k3
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18F-FDG?PET???????????????????? ??????????????????
??????? ??????????? 123I-IMP???SPECT??????????????
????????????? (Patlak plot ?)????? 3
????????????????????? Ki (????????? K1, k2, k3
?????????? ????????????????????)???? Vd (K1, k2,
k3 ????????????????? ???? Distribution Volume
??????)???? ????????Patlak plot ??
?????? (????????????????????? patlak.doc ???)
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Patlak plot ??
t
?Cp
X(t)
Ki Vd
Cp(t)
Cp(t)
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X(t) ??SPECT?????????????? 123I-IMP ????Patlak
plot ??? Ki ?? ????????????( ml / min / 100g
brain)? Patlak plot ???????????? 3
?????????????????????? k4 0 (
????????????????
???????????????? ) ??? IMP ? k4 ????? 0
??????? ?????????
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???SPECT ????????? 123I-IMP????
99mTc-HMPAO?99mTc-ECD ???? 99mTc???????????
???????????(740MBq)????????? (123I-IMP ? 111
MBq) 99mTc-HMPAO??????99mTc???????????
????????????????????? (ECD???????????????????)
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99mTc-ECD??????????????? ??????
5???????(HMPAO?10??IMP?20?) ???????????????????
?? ???????????????? (????????)?
(??????????????????????1? ????????????ECD???????
???? ??????????????????????????
????????????????????)
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99mTc-HMPAO?99mTc-ECD ????IMP????????? ???????????
??????????????? ????????????????????? ????????????
??????????(???? ??)?????(ROI)?????????????? Patlak
plot?????????????????????
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123I-IMP ??? IMP ?????????????????? ECD?HMPAO?????
???????????? ???????????? ????????????????? ?????
????????? ????????????? ?????IMP?????? (
??????????? 99mTc???????????? ???SPECT???????)
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• 99mTc-HMPAO
• ( hexa methyl propylene amine oxime )
• ???????????
• ?????BBB??????????????
• ?????????????????BBB???
• ?????????????????
• ?????????????????
• ?????????????????
• 99mTc 370740 MBq ????30???????
• ??10???SPECT??(20??)?

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MRA MRI T2
99mTc-HMPAO Brain perfusion SPECT ????????
???????????? MRI T2????????????????????????????
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• 99mTc-ECD brain SPECT
• 99mTc 141keV LEHR ?????
• 99mTc-ECD (ethyl cysteinate dimer)
• 400800MBq ????? 5?????????
• SPECT? (128x128??????) ?20????.
• ?????????????????
• ECD???????????BBB(?????)?
• ????????????
• ????????????????????
• ??????BBB????????????????

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99mTc-ECD Brain SPECT
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