Poster Draft from Bioengineering

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Poster Draft from Bioengineerings Capstone
Design Course
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(No Transcript)
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Add Dept. of BIOE and contact info
Cut
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NanoStitch
A Nanoshell Assisted Laser Tissue Welding Device
Team Lazer, Rice University Presented by Karl
Balsara, Marc Burrell, Mike Cordray and Sanjay
Maniar
Good decision to use bold to call attention to
description of your design, but this large block
of text doesnt provide an easy entry point into
the poster. Reorganize and edit!
Introduction
Technical Specifications
Nanostitch
Cutting-edge nanoshell technology offers a new
wave of biomedical research that can be directly
applied to the clinical setting. While current
methods of wound closure, such as sutures and
liquid adhesives, encounter problems arising from
scarring, cost, infection and inconvenience,
current research has shown promising results for
the implementation of nanoshells in the field of
laser tissue welding1. A significant setback to
current laser wound closure techniques is the
large user variability. To address the pitfalls
of previous wound closure techniques, Team Lazer
has designed and built a prototype of an easily
applicable device and a user-friendly program to
address the concerns of safety and consistency
arising from the variables of laser distance,
angle, and motion along with the surface
temperature of the skin.
Laser FAP I Laser System made by Coherent Inc., Output 14 W/cm² Spot Size 5 mm spot size
Solder Solution Gold nanoshells peak absorbance of 821 nm Nanoshell suspension of 7x1010 particles/ml
Temperature Sensor Raytek MI Series System response time of 150 ms
Proximity Sensor Banner U-Gage S18U Analog Sensor Measures distance between 3cm 30cm
Software Built in LABVIEW, easily upgradable Easy to use Interface
Laser Mounting Bracket
Temperature Sensor
Motor
Safe and Effective Solution
Device Concept

• Insert table of Nanostitch vs handheld laser
  application to show increased consistency (lower
  standard deviation) for device
• Results coming

• Insert graph of tensile strength of Nanostitch
  vs. Suture
• Results coming

Proximity Sensor

• Size of Wound 2-5cm
• Maximum Safety
• Highly Consistent
• Highly Repeatable

Dampened Arm
Safety Concerns Addressed
Conclusions
User Interface

• Current methods of wound closure are
  inconvenient and increase patients
  susceptibility to infection and scarring
• Incorporation of distance and temperature
  sensors into a user-friendly software program
  results in a safer and more consistent wound
  closure

• Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound ? Less opportunity
  for infection
• Motorized angle adjustment allows for consistent
  application to skin
• User Safety
• User interface alarms operator when critical
  temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off System

• Visible alarms
• Temperature at wound and distance to wound
  highly visible
• Emergency stop button to cut laser power
• Easy calibration to ensure consistency between
  trials
• Visible indication of current laser power

Acknowledgments and References

• 1. Gobin AM, O'neal DP, Watkins DM, Halas NJ,
  Drezek RA, West JL. Near infrared laser-tissue
  welding using nanoshells as an exogenous
  absorber. Lasers Surg Med. 2005 Aug37(2)123-9.
• Special Thanks to
• Andre Gobin
• Dr. Jennifer West, Rice University
• Dr. Oden, Rice University
• CBEN
• Brown Foundation Teaching Grant

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Cut s in Costs
Why report volume in ft3?
Re-order based on importance or group by implicit
logical categories
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Dont justify line spacing because it creates odd
spaces between words.
Lower case s
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Nice large image to highlight design, but replace
with image of device put together. Use callouts
for key components.
Serif font
Explain how it works.
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Whats the purpose of this section? The text
bullets seem to explain the obvious.
Use one font consistently.
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Need to describe testing.
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Need to report results in more detail.
Whats this?
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These arent conclusions. Focus on your designs
features and advantages
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Use paragraph form to create more space above
for testing and results.
Capital N
Spell out CBEN.
Italicize journals.
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Revised poster . . .
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NanoStitch
A Nanoshell Assisted Laser Tissue Welding System
Team Lazer, Department of Bioengineering, Rice
University Presented by Karl Balsara, Marc
Burrell, Mike Cordray and Sanjay
Maniar teamlazer_at_gmail.com
Introduction
NanoStitch
User Interface
How it Works
Current methods of wound closure, such as sutures
and liquid adhesives, lead to increased scarring,
cost, inconvenience, and possibility for
infection. A new approach that combines nanoshell
technology with laser tissue welding1 appears
promising. However, the problem of user
variability remains to be solved. Team Lazer has
designed and built a prototype of an easily
applicable device and a user-friendly software to
address the concerns of safety and consistency
arising from the variables of laser distance,
angle, and motion along with the surface
temperature of the skin.

• Set Up
• Laser adjusted to desired conditions
• Distance and temperature sensor calibrated

• Sample Preparation
• Chicken samples isolated
• Nanoshell solder applied directly to wound

NanoStitch Concept

• Prototype Requirements
• Easily Portable
• Maximum Safety
• Cost lt 5 per use
• Cost lt 1500 per device
• Operable with minimal training
• Highly Consistent Repeatable
• Operator friendly computer interface

• Safety Feedback Mechanisms
• If temperature becomes too high, alarms trigger
  operator and laser intensity ramped down
• Operator notified of distance to wound in
  real- time to ensure consistency

• Size of Wound 2-5cm
• Volume lt 2m³
• Sensing Distance 2-10cm

• Commence Annealing Process
• Laser shined over wound to begin closure
• Motor adjusts angle of laser to maintain surface
  exposure

Safe, Successful Wound Closure!!
Safety Concerns Addressed
Conclusions
Safe and Effective Solution

• Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound ? Less
  opportunity for infection
• Motorized angle adjustment allows for consistent
  application to skin
• Operator Safety
• Alarms when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off system

• Mechanical tensile failure tests were
  implemented to determine efficacy of NanoStitch
• No significant difference between tensile
  strength of NanoStitch and Suturing Technique
  (two-sample t-test, alt0.05)
• NanoStitch exhibits significantly greater
  Youngs Modulus over Handheld technique
  (two-sample t-test, alt0.05)
• Qualitative analysis illustrate more frequent
  failure at grip site, rather than welding site,
  during NanoStitch testing

• NanoStitch goes one step further than
  conventional hand-held laser tissue welding
  technology.
• The incorporation of real-time feedback
  controlled distance and temperature sensors into
  a user-friendly software program results in a
  safer and more consistent wound closure.

Acknowledgments and References
Method of Wound Closure Young's Modulus Yield Point Ultimate Tensile Stress
NanoStitch (n5) 0.044 0.009 N/mm² 0.019 0.027 N/mm² 0.013 0.0038 N/mm²
Handheld (n5) 0.028 0.016 N/mm² 0.013 0.022 N/mm² 0.008 0.0055 N/mm²
Suture (n5) 0.030 0.016 N/mm² 0.012 0.006 N/mm² 0.015 0.011 N/mm²
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ,
Drezek RA, West JL. Near infrared laser-tissue
welding using nanoshells as an exogenous
absorber. Lasers Surg Med. 2005
Aug37(2)123-9. Special Thanks Team Lazer
would like to thank Andre Gobin, Dr. Jennifer
West, Dr. Maria Oden, Joseph Gesenhues, the
Center for Biological and Environmental
Nanotechnology and the Brown Foundation Teaching
Grant for all of their help and support
throughout the entire design process.
15
NanoStitch
A Nanoshell Assisted Laser Tissue Welding System
Team Lazer, Department of Bioengineering, Rice
University Presented by Karl Balsara, Marc
Burrell, Mike Cordray and Sanjay
Maniar teamlazer_at_gmail.com
Introduction
NanoStitch
User Interface
How it Works
Current methods of wound closure, such as sutures
and liquid adhesives, lead to increased scarring,
cost, inconvenience, and possibility for
infection. A new approach that combines nanoshell
technology with laser tissue welding1 appears
promising. However, the problem of user
variability remains to be solved. Team Lazer has
designed and built a prototype of an easily
applicable device and a user-friendly software to
address the concerns of safety and consistency
arising from the variables of laser distance,
angle, and motion along with the surface
temperature of the skin.

• Set Up
• Laser adjusted to desired conditions
• Distance and temperature sensor calibrated

• Sample Preparation
• Chicken samples isolated
• Nanoshell solder applied directly to wound

Overall, revised poster contains an appropriate
balance of text and visuals. Excellent use of
images, text boxes, and arrows to represent the
device and how it works. Use of red/blue in this
section provides additional coherence. Layout is
accessible. Material is comprehensible.
Formatting is consistent.
NanoStitch Concept

• Prototype Requirements
• Easily Portable
• Maximum Safety
• Cost lt 5 per use
• Cost lt 1500 per device
• Operable with minimal training
• Highly Consistent Repeatable
• Operator friendly computer interface

• Safety Feedback Mechanisms
• If temperature becomes too high, alarms trigger
  operator and laser intensity ramped down
• Operator notified of distance to wound in
  real- time to ensure consistency

• Size of Wound 2-5cm
• Volume lt 2m³
• Sensing Distance 2-10cm

• Commence Annealing Process
• Laser shined over wound to begin closure
• Motor adjusts angle of laser to maintain surface
  exposure

Safe, Successful Wound Closure!!
Safety Concerns Addressed
Conclusions
Safe and Effective Solution

• Patient Safety
• Temperature monitoring prevents damage to skin
• Modulated laser intensity to prevent burns
• Reduced manipulation of wound ? Less
  opportunity for infection
• Motorized angle adjustment allows for consistent
  application to skin
• Operator Safety
• Alarms when critical temperature is reached
• Proximity to skin determined in real-time
• Automatic Shut-off system

• Mechanical tensile failure tests were
  implemented to determine efficacy of NanoStitch
• No significant difference between tensile
  strength of NanoStitch and Suturing Technique
  (two-sample t-test, alt0.05)
• NanoStitch exhibits significantly greater
  Youngs Modulus over Handheld technique
  (two-sample t-test, alt0.05)
• Qualitative analysis illustrate more frequent
  failure at grip site, rather than welding site,
  during NanoStitch testing

• NanoStitch goes one step further than
  conventional hand-held laser tissue welding
  technology.
• The incorporation of real-time feedback
  controlled distance and temperature sensors into
  a user-friendly software program results in a
  safer and more consistent wound closure.

Acknowledgments and References
Method of Wound Closure Young's Modulus Yield Point Ultimate Tensile Stress
NanoStitch (n5) 0.044 0.009 N/mm² 0.019 0.027 N/mm² 0.013 0.0038 N/mm²
Handheld (n5) 0.028 0.016 N/mm² 0.013 0.022 N/mm² 0.008 0.0055 N/mm²
Suture (n5) 0.030 0.016 N/mm² 0.012 0.006 N/mm² 0.015 0.011 N/mm²
1. Gobin AM, O'neal DP, Watkins DM, Halas NJ,
Drezek RA, West JL. Near infrared laser-tissue
welding using nanoshells as an exogenous
absorber. Lasers Surg Med. 2005
Aug37(2)123-9. Special Thanks Team Lazer
would like to thank Andre Gobin, Dr. Jennifer
West, Dr. Maria Oden, Joseph Gesenhues, the
Center for Biological and Environmental
Nanotechnology and the Brown Foundation Teaching
Grant for all of their help and support
throughout the entire design process.