Dog with Dehydration and Acute Abdominal Pain

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Dog with Dehydration and Acute Abdominal Pain

• Dennis B. DeNicola, DVM, PhD, DACVP
• Chief Veterinary Educator
• IDEXX Laboratories

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Salem

• 5 years old
• Intact male
• Mixed breed dog
• Presented with the primary clinical problem of
  acute onset abdominal pain
• Moderately dehydrated

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Salem - 5 Year-old, Mixed Breed
WBC 34.16 K/?L HIGH ( 5.50
16.90 ) LYM 1.48 K/?L ( 0.70
4.90 ) MONO 2.38 K/?L HIGH ( 0.10
1.40 ) NEU 29.72 K/?L HIGH ( 2.00
12.00 ) EOS 0.39 K/?L ( 0.10
1.49 ) BASO 0.19 K/?L HIGH ( 0.00
0.10 ) LYM 4.3 MONO 7.0 NEU 87.0
EOS 1.1 BASO 0.6 HCT 49.5 ( 37.0
55.0 ) RBC 6.88 M/?L ( 5.50 8.50
) HGB 16.0 g/dL ( 12.0 18.0
) RETIC 33.1 K/?L RETIC 0.5 MCV 71.
9 fL ( 60.0 72.0 ) RDW 16.1 ( 14.7
17.9 ) MCHC 32.3 g/dL ( 31.0 37.0
) MCH 23.21 pg ( 19.50 24.50 ) PLT 253
K/?L ( 175 500 ) MPV 14.31 fL PCT 0.4 P
DW 18.4
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Salem - 5 Year-old, Mixed Breed
Erythron HCT 49.5 ( 37.0 55.0
) RBC 6.88 M/?L ( 5.50 8.50
) HGB 16.0 g/dL ( 12.0 18.0
) RETIC 33.1 K/?L RETIC 0.5 MCV 71.9
fL ( 60.0 72.0 ) RDW 16.1 ( 14.7
17.9 ) MCHC 32.3 g/dL ( 31.0 37.0
) MCH 23.21 pg (19.50 24.50 )
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Erythron Data Interpretation

• Anemia
• Moderately severe
• Macrocytic (?MCV)
• Hyperchromic (?MCHC) hemolytic specimen
• Regenerative (?Reticulocyte Count)
• Moderate anisocytosis (?RDW)

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Erythron Blood Film
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Erythron Blood Film
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Erythron Blood Film
Rouleaux
Agglutination
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Saline Agglutination Test
Saline Solution
Agglutination
Rouleaux
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Erythron Blood Film
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Erythron Blood Film
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Erythron Blood Film Interpretation

• Anemia
• Moderately severe
• Regenerative
• Polychromasia
• Anisocytosis
• Immune mediated extravascular hemolysis
• Spherocytosis
• Suggestion of autoagglutination
• Requires saline dilution confirmation

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Salem - 5 Year-old, Mixed Breed
Leukon WBC 34.16 K/?L HIGH ( 5.50 16.90
) LYM 1.48 K/?L ( 0.70 4.90
) MONO 2.38 K/?L HIGH ( 0.10 1.40
) NEU 29.72 K/?L HIGH ( 3.00
12.00 ) EOS 0.39 K/?L ( 0.10 1.49
) BASO 0.19 K/?L HIGH ( 0.00 0.10
) LYM 4.3 MONO 7.0 NEU 87.0
EOS 1.1 BASO 0.6
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Salem - 5 Year-old, Mixed Breed
Leukon WBC 34.16 K/?L HIGH ( 5.50 16.90 )
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Salem - 5 Year-old, Mixed Breed
Leukon WBC 34.16 K/?L HIGH ( 5.50 16.90 )

• Leukocytosis
• Mild

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Salem - 5 Year-old, Mixed Breed
Leukon WBC 34.16 K/?L HIGH ( 5.50 16.90
) LYM 1.48 K/?L ( 0.70 4.90
) MONO 2.38 K/?L HIGH ( 0.10 1.40
) NEU 29.72 K/?L HIGH ( 3.00
12.00 ) EOS 0.39 K/?L ( 0.10 1.49
) BASO 0.19 K/?L HIGH ( 0.00 0.10
) LYM 4.3 MONO 7.0 NEU 87.0
EOS 1.1 BASO 0.6
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Salem - 5 Year-old, Mixed Breed
Leukon WBC 34.16 K/?L HIGH ( 5.50 16.90
) LYM 1.48 K/?L ( 0.70 4.90
) MONO 2.38 K/?L HIGH ( 0.10 1.40
) NEU 29.72 K/?L HIGH ( 3.00
12.00 ) EOS 0.39 K/?L ( 0.10 1.49
) BASO 0.19 K/?L HIGH ( 0.00 0.10
) LYM 4.3 MONO 7.0 NEU 87.0
EOS 1.1 BASO 0.6

• Leukocytosis
• Mild
• Mild neutrophilia and monocytosis
• Minimal basophilia

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Leukogram Interpretation

• Mild leukocytosis
• Mild neutrophilia and monocytosis
• Minimal basophilia insignificant
• No significant lymphocytopenia
• Inflammation

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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukon Blood Film
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Leukogram Interpretation

• Mild leukocytosis
• Mild neutrophilia and monocytosis
• Minimal basophilia insignificant
• No significant lymphocytopenia
• Inflammation

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Leukogram Interpretation

• Mild leukocytosis
• Mild neutrophilia and monocytosis
• Minimal basophilia insignificant
• No significant lymphocytopenia
• Inflammation
• Mild left shift with hyposegmented neutrophils
• Mild toxicity

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Leukogram Interpretation

• Mild leukocytosis
• Mild neutrophilia and monocytosis
• Minimal basophilia insignificant
• No significant lymphocytopenia
• Inflammation
• Mild left shift with hyposegmented neutrophils
• Mild toxicity
• Moderate inflammation

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Salem - 5 Year-old, Mixed Breed
WBC 34.16 K/?L HIGH ( 5.50
16.90 ) LYM 1.48 K/?L ( 0.70
4.90 ) MONO 2.38 K/?L HIGH ( 0.10
1.40 ) NEU 29.72 K/?L HIGH ( 2.00
12.00 ) EOS 0.39 K/?L ( 0.10
1.49 ) BASO 0.19 K/?L HIGH ( 0.00
0.10 ) LYM 4.3 MONO 7.0 NEU 87.0
EOS 1.1 BASO 0.6 HCT 49.5 ( 37.0
55.0 ) RBC 6.88 M/?L ( 5.50 8.50
) HGB 16.0 g/dL ( 12.0 18.0
) RETIC 33.1 K/?L RETIC 0.5 MCV 71.
9 fL ( 60.0 72.0 ) RDW 16.1 ( 14.7
17.9 ) MCHC 32.3 g/dL ( 31.0 37.0
) MCH 23.21 pg ( 19.50 24.50 ) PLT 253
K/?L ( 175 500 ) MPV 14.31 fL PCT 0.4 P
DW 18.4