Surface Coatings

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Surface Coatings
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General strategies to Prevent Device-related
Infections

• Minimize contact- Clean Room Conditions
• Kill every thing in contact-Sterilization
• Minimize binding at contact-Surface coating
• Kill after contact-Anti-infective coatings

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Protein Adsorption in situ
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Protein Adsorption in situ
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No Protein Adsorption
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Surface Coating Technology

• Change surface chemistry without changing
  mechanical properties
• Alter binding properties for proteins and other
  molecules to improve device performance
• Surface coating technology increases range of
  performance and, in general, requires less
  capital investment and less dramatic changes in
  manufacturing practices.

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Methods

• Plasma or corona treatment in the presence of a
  reactive atmosphere
• Adsorption and,
• Covalent Immobilization
• The objective is to create a minimally reactive
  surface by creating an interface that is
  invisible to the system or one that is
  specifically activated to control cell behavior
  at the interface.

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Surface Modification Using Low-Pressure Plasma
Technology
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PLASMA APPLICATIONS
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Table I. Typical material surface-tension and
contact-angle values
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Surfactant-based Biomaterial Coating
PEO
PPO
PEO
HO
OH
129
56
129
-CH-CH2-O-
-CH2-CH2-O-

CH3
Hydrophobic Substrate Contact angle gt70
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Inhibition of Cell Attachment
GFAP Green
Light Micrograph
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Phospholipids
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Phosphorylcholine Derivatives
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Covalent Immobilizaiton
Heparin coated after blood exposure
Uncoated after blood exposure with microthrombus
on surface
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Emerging Technologies

• Coatings for enhanced imaging
• Cell coated grafts for tissue engineering
• Coating to enhance regenerative processes
• Coatings for drug delivery

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Coating Companies

• Polymer Technology GroupSurModicsCarmedaHydrom
  er Inc.AST Products Inc.STS BiopolymersBiocoat
  Richard James Inc.Biocompatibles
  Ltd.BioChromSurface Solutions
  LaboratoriesSpire Corp.Implant Sciences
  Corp.Advanced Polymer Systems Inc.