Paget's Disease of the Bone

1
Paget's Disease of the Bone

• Audrey Pekarik

2
What is Paget's Disease

• Paget's disease is a chronic disease that leads
  to enlarged and misshapen bones. The bone's
  remodeling is disturbed and not synchronized.
  This causes the bone to be enlarged, not as
  dense, and brittle. The disease becomes more
  common with age.

3
What Causes Paget's

• It is not entirely known what causes Paget's
  disease. However, certain genes have been
  associated with it such as theSequestrosome 1
  gene on chromosome 5. Also, viral infection may
  be necessary to trigger the disease in people who
  have inherited the gene.

4
Symptoms

• Most of the time there are no symptoms and it is
  often found on x rays taken for another reason.
  Paget's disease can cause bone-pain, deformity,
  fractures and arthritis. The pain is located in
  the affected bone.The most common bones affected
  are the spine, femur, pelvis, skull, clavicle,
  and humerus.

5
Symptoms Continued

•  Other symptoms depend on which bones are
  affected. Enlarged bones can pinch nerves and
  cause tingling and numbness. If the disease
  affects the hips or knees it can cause arthritis,
  limping, and pain or stiffness of the knee or
  hip. If it affects the legs, they can become
  bowed. If the skull is affected it can cause
  headaches, and loss of hearing and vision. If the
  disease is wide spread, congestive heart failure
  can occur because of the high workload for the
  heart.

6
Diagnosis and Prognosis

• Paget's disease is diagnosed based on x ray
  appearance as well as possible bone scans, MRI
  scans, or CT scans. Also blood tests are used
  because an enzyme that comes from bone, alkaline
  phosphatase, is usually elevated in people who
  have Paget's disease because of the abnormal
  remodeling.
•  
• The prognosis is generally good. The symptoms
  progress slowly and the disease doesn't spread to
  healthy bones like cancer. However, there is no
  cure.

7
Treatment

• Since there is no cure, the goal of the treatment
  is to control the disease's activity and the
  complications. When there are no symptoms or
  elevated levels of alkaline phosphatase, then
  treatment isn't necessary. Bone pain can require
  NSAIDs. Deformity can require supports. Surgery
  may be necessary for damaged joints, fractures,
  severely deformed bones, or when nerves are being
  pinched by enlarged bone. Medications such as
  bisphosphonates or injectable calcitonin may be
  used.

8
Works Cited

• http//www.medicinenet.com/pagets_disease/page2.ht
  m
•  http//www.mayoclinic.com/health/pagets-disease-o
  f-bone/DS00485/DSECTIONsymptoms
• http//en.wikipedia.org/wiki/Paget27s_disease_of_
  bone
• http//uwmsk.org/static/residentprojects/paget8511
  .jpg