Clinical Trials Update

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• Clinical Trials Update
• June 24th 2005

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Our Consortium
Jameson, New Castle
Murtha CC, Johnstown
AGH
UPMC Hillman
Somerset
Mercy
UPMC McKeesport
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RTOG Membership

• UPMC McKeesport (February 2005)
• Mercy Hospital (Previous member)
• UPMC Murtha (June 2005)
• Somerset Cancer Center (pending)
• Jameson Hospital (pending)

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The Clinical Trials

• High Priority Trials
• RTOG 0420
• TMZ/XRT followed by TMZ-CPT11 for GBM
• IRB approved 2/05
• Accrued 2 patients
• RTOG 0235
• PET pre- post-treatment for locally advanced
  NSCLC
• Under IRB review, anticipate approval July/August
  2005
• RTOG 0214
• PCI for NSCLC after definitive chemoradiotherapy
• IRB approved

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Clinical Trials (cont)

• NSABP B39/ RTOG 0431
• Whole breast irradiation vs. Partial breast
  irradiation for early stage breast cancer
• Currently under IRB review
• CDRP Lung (Wynn)
• Amifostine to minimize treatment breaks for NSCLC
• Under IRB review anticipate approval July/August
  2005