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AUTISM A 3 Stage Approach
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Treatment Proposal

• Research Protocol
• Why? - Wheres the evidence?
• Open, prospective design
• Look See
• Evaluate 3 stages
• Exclusion diet
• Supplements
• Homeopathic Remedy

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Care Pathway for ASD

• Initial Assessment
• History
• Conventional
• Dietary
• Homeopathic
• Rating Scale
• ATEC (Autism Treatment Evaluation Checklist)
• SRS (Social Responsiveness Scale)
• Video Footage ?
• home videos
• at the clinic

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Care Pathway for ASD

• Consider Further Tests
• Blood
• Heavy Metals ? (
  N-Acetylcysteine / L-Glutathione)
• Coeliac Screen
• Food Intolerance (IgG York Laboratories)
• Nutritional Screen
• EFAs / Vitamins / Minerals
• Stool
• Parascope

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Care Pathway for ASD

• 1. Diet Regime
• WF / DF / YF (wheat / dairy / yeast)
• LGI (low glycaemic index)
• Protein Rich
• If also ADHD Traits
• SF / AF (sugar / additives)
• Salicylates
• Aubergines

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Care Pathway for ASD

• 2. Supplements
• A. Gut Support
• L-Glutamine (amino acid)
• MSM (methyl sulfonyl methane)
• Digestive enzymes
• Probiotic (Lactobacillus Acidophilus /
  Rhamnosus)
• B. Nutritional
• Vitamins
• Minerals
• N-Acetyl-Cysteine
• a-Lipoic acid
• O 3 EFAs (Essential Fatty Acids Fish Oils)
• EPA / DHA (Ratio 3 / 2)

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Care Pathway for ASD

• 3. Homeopathic Treatment
• Individualised remedy
• Tailored for the individual
• Ignore the Characteristic ASD presentation
• Most have these features in common

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Care Pathway for ASD

• Exclusion Diet
• 3 Months
• Add - Dietary Supplements
• 3 Months
• Add - Homeopathic Treatment
• 3 Months
• Follow up for 1 year
• 3 monthly intervals

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Care Pathway for ASD

• Evaluation
• Initial Assessment
• 3 Monthly x 3
• Diet / Supplements / Homeopathic
• 6 Monthly x 2
• On all 3 regimes
• Tools
• Rating scales
• ATEC / ARS
• Video Footage ?
• Independent external observer

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Referrals for the study

• Privately
• On the NHS GP referral
• Ideas is to provide the whole package
• Assessment
• Selected tests
• Diet advice
• All supplements
• Homeopathic remedy

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Axis ADHD - ASD Co-Morbidity
ADHD
Autism
Soft Neurological Signs Dyspraxia / Dyslexia /
In-coordination
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L - GLUTAMINE

• C5H10N2O3
• Amino Acid
• Amino group
• Acidic carboxyl group

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L-Glutamine Gut

• Major fuel for enterocytes colonocytes
• Maintain integrity function (Barrier) of
  intestinal mucosa
• Increase villus height Reduce permeability
• Reduce Leaky gut syndrome symptoms
• Helps desensitise against food intolerance
• Protect against injury inflammation (NSAIDs
  damage)
• Restore ulcers Prevent apoptosis
• Help against IBD ( Crohns UC)
• Alleviates devastating damage from chemotherapy
• Helps maintain secretory IgA
• Preventing the attachment of bacteria to mucosal
  cells
• Inhibit translocation of Gram-negative bacteria
  from colon

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L-Glutamine - Immune system

• Boost of the immune system by increasing
• T-lymphocytes
• CD4 levels CD4 CD8 ratio
• Ratio of T-helper / T-suppressor cells
• Interleukin-2 receptor bearing lymphocytes
  proliferation
• Macrophage proportion of TNF-?
• Interleukins-1? 6
• Neutrophil activity
• Glutamine supplements showed clinically
• Fewer infections
• Increased T-cell recovery
• In bone marrow transplant patients
• Enhanced T-cell response
• Patients undergoing surgery / suffering from
  acute pancreatitis

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L-Glutamine - Anti-Oxidant

• Glutamine raises tissue glutathione levels
• with Cysteine Glycine
• Glutamine dependent enzyme
• Thus, protecting against Oxidative stress
• Reducing free radicals
• Reduction of Nitric oxide accumulation

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L-Glutamine - Brain Function

• Glutamine is an Important fuel for the brain
• Provide adequate energy in the absence of glucose
• Brain concentration levels 10 to 15 times
  greater than in blood
• Improve glucose homeostasis
• Glutamine acts as a substrate for modulator
  between
• Inhibitory effects of Gamma Aminobutyric Acid
  (GABA)
• Stimulating effects of Glutamate
• Glutamine improves cognitive function
• Concentration Focus
• Alertness Energy
• Memory
• Mood
• Eliminate brain fuzziness and  low mental
  energy symptoms
• Associated with low carbohydrate diets (Athletes
  Bodybuilders) 

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Homeopathy

• Christian Friedrich Samuel Hahnemann
• 1755 1843 (Meissen, Saxony)

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HahnemannBas Relief Washington Monument

• Student

• Chemist

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Like Cure Like

• Cinchona officinalis
• Peruvian Bark
• Source of QUININE
• The anti-malarial drug
• Symptoms of Malaria
• Fever
• Chills
• Sweating
• Shaking / Rigors

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Law of Similars

• From the Greek words
• Homeo Similar
• Pathos Suffering
• Similar Suffering
• Homeopathy

• Similumum similibus curentur
• Let like be cured by like

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Law of Similars states

• A substance which will produce a set of symptoms
  in a healthy person
• Will cure those same symptoms when they are found
  as part of a natural disease
• Previously described by
• Hippocrates and Paracelsus

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Symptom Pictures Materia Medica

• Remedies made from
• Animal / Plant / Mineral kingdom
• Obtained from 3 main sources
• Provings
• Testing on healthy volunteers
• Accidental Poisonings
• Mainly from industrial exposure
• Clinical Evidence
• Verification of cured symptoms

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Examples of Like Cure Like

• Conventional
• Ritalin for ADHD
• Vaccinations against childhood diseases
• Natural
• Onion Hayfever
• Coffea Insomnia
• Nettle Urticaria
• Apis Bee sting

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Principles of Homeopathy

• 1st Edition - 1810
• Presented to the
• medical profession

• 6th Edition - 1921
• Published 78 years after
• Hahnemanns death

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Homeopathy

• Complete system of healing based on natural laws
• Safe
• Gentle
• Effective (Cost)
• Environmentally conservative
• Affordable (Cheap)
• Perfect preventative Medicine
• Reduces susceptibility to external stimuli
• Ideal for chronic diseases
• Reduce need for conventional medicines
• Practiced in most countries (India)
• Mainly in Primary care

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Unique form of Medicine

• Homeopathy allows
• INDIVIDUALIZED
• System of medicine
• STIMULATION of bodies
• Own Healing mechanisms
• HOLISM concept
• Looking at the whole person

• Homeopathic medicines come in many forms
• Liquid
• Cream
• Tablets / Pillules
• Lactose / Sucrose

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Royal London Homeopathic Hospital

• Established in1849
• Dr. Quinn
• 200 inpatient beds
• Cholera epidemic in 1854
• 54,000 people died
• Allopatic mortality 59.2
• Homeopathic mortality 16.4
• Expansion in 1859
• New extension 1895
• Queen Square wing
• 300 beds
• Rebuild expanded in 1948
• Severely damaged in WW II
• Refurbished in 2002
• Only outpatients

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Europes largest public funded centre for
integration of complementary medicine
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YOUR RIGHT TO NHS CHOICE Choose and Book Free
Choice
NHS Service Allows patients to be seen at any
hospital of their choice under the NHS Most
GPs now use Choose and Book Your GP can access
the RLHH services directly
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Integrated complementary servicesRoyal London
Homeopathic Hospital

• Acupuncture
• for knee, back pain headache
• Chronic Fatigue Syndrome Clinic
• Fibromyalgia Services
• General Medicine
• Cancer Care Services
• Allergy Services
• Childrens Clinic
• Podiatry Chiropody (Marigold)
• Skin Clinic
• Holistic Antenatal Clinic
• Womens Health Service

• Musculoskeletal Medicine
• Spinal Manipulation
• Rheumatology Clinic
• Physiotherapy
• Occupational Therapy
• Dietetic Nutritional Services
• Stress, Anxiety Mood Disorders
• Psychosomatic medicine
• Medical Clinical Hypnotherapy
• Relaxation Visualisation
• Cognitive Behaviour Therapy
• Autogenic Training Clinic

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For more information ask your GP

• www.chooseandbook.nhs.uk
• www.uclh.nhs.uk
• www.uclh.nhs.uk/ourhospitals/RLHH.htm
• CAMLIS

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How to get to the RLHH

• Address
• 60 Great Ormond Street
• London WC1N 3HR
• 020 7391 8888
• By Tube
• Russell Square (Picadilly line)
• Holborn (Central line)
• By Bus
• Southampton Row (59, 68, 91, 168, 188, 501)
• Theobald Road (19, 38, 55, 243)
• High Holborn / New Oxford Street (8, 25, 242,
  501, 521)

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ASD Is Treatable

• Diagnosis
• Nutritional support
• Exclusion Diet
• Supplementation
• Homeopathic
• Individualisation