Homeopathy: Something from

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HomeopathySomething from Nothing?

• Lynn S. Peck, DVM, M.S.
• Gainesville, Florida

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Things You Already Know
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Things You Already Know

• The existence of one type (of system) does not
  eliminate the possibility of the existence of
  another type (of system)
• Cell signalling
• Physico-chemical (chemical bonds)
• Electromagnetic (wavelength frequency)
• Quantum???

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Vibration/Oscillation and Cell Function

• Cells and intracellular elements are capable of
  vibrating in a dynamic manner with complex
  harmonics, the frequencies of which can now be
  measured. Pienta, KJ and Coffey, DS. Med Hypoth
  (1991) 34, 88-95
• These vibrations can be altered by growth
  factors and carcinogenesis.
• Vibration/oscillation required for function
• O2 transport in/out of myoglobin
• Cell membrane phospholipids for protein folding
• Protein structural vibrations _at_ enzyme active
  sites
• Ca2 ion oscillation at Purkinje cell membranes
  causes heartbeat rhythm

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Cellular Vibration

• DNA G-C base pairs 3.3 x 10 12 sec
• A-T base pairs 2.8 x 10
  12 sec
• Strand 5 x 10 11 sec
• Protein vibration 10 12 to 1 sec
• Ion Flux 0.4 to 100 sec

From Pienta, KJ and Coffey, DS. Med Hypoth (1991)
34, 88-95
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Fourier Analysis of Motility of 2 Fibroblast Cells
Pienta, KJ and Coffey, DS. Med Hypoth (1991) 34,
88-95
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Cell Signalling

• Popp (1976) Biophoton emissions from DNA
• Coherent light (in phase highly ordered)
• Different frequencies stimulate different cell
  functions and different molecules
• Photon emissions
• Humans 10 photons/cm2/sec _at_ 200-800 nm
• Plants and simple animals 100 photons/cm2/sec
• Repeating pattern cycles at 7, 14, 32, 80, 270
  days

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Cell Signalling

• Popp (1976) Biophoton emissions from DNA
• Photon emissions, disease, and health
• Cancer patients loss of coherence, rhythms
• Multiple Sclerosis too highly ordered
• Stress increased biophoton emissions
• Health lowest number of emissions
• Plant extracts change cancer cell biophoton
  emissions?
• Mistletoe

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Water
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Water

• A liquid crystal with a pliable lattice matrix
• Many unique properties
• 2 gases liquid at normal temperatures
• Expands as it freezes less dense

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Water and Dilution

• HCl or NaOH added to highly dilute solutions of
  themselves resulted in a (2 to 40 x) greater heat
  of dilution than when added to water alone
• Persisted for weeks Elia and Niccoli, 1999, Ann
  NY Acad Sci 879241-248
• Adding water to an aqueous solution of NaCl, DNA,
  cyclodextrin, or other substances caused
  molecules to form insoluble aggregates
  (buckyballs) 5 to 10 x larger than those in
  original solution Geckler and Samal, 2001
• The more dilute the original solution, the larger
  the aggregates (laser scattering and SEM)
• 10-1 10 12 (1 to 12 CH)

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Water Organizational Properties

• Coherent domains around charged molecules.
• Shaking/agitation speeds up this process?
  Preparata G and Del Guidice E
• Appears to conduct and amplify a molecules
  signature frequency Benveniste, J
• Organizes to form pattern imprinted with wave
  information?
• Stores and carries a frequency so it can be
  read at a distance?
• May have role in organizing discordant energy
  into coherent photons

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Jacque Benvenistes Studies

• M.D., Allergist, Director of Research French NIH
• Discoverer of Platelet Activating Factor
• Basophils and anti-IgE antibodies
• Anti-IgE inhibits basophil absorption of dye
• Serial dilutions of anti-IgE to 1 part in 1060,
  10120 still inhibited dye absorption
• Replicated in 5 labs, 4 countries, 13 scientists,
  4 yrs, gt300 trials (Nature, 1988)
• Replicated by challengers in 3 of 4 labs in 4
  countries Inflamm Res, 1996, Suppl 1 S33-4
• The results compel me to suspend my disbelief
  and to start searching for rational explanations
  for our findings- M Ennis

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Benveniste Basophil Degranulation After Exposure
to Anti-Ig E (log dilutions) Nature, 1988
333(6176) 816-8
110 series
1100 series
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Jacque Benvenistes Studies

• specific information must have been transmitted
  during the dilution/shaking process. Water could
  act as a template for the molecule, for example,
  by an infinite hydrogen bonded network, or
  electric and magnetic fieldsThe precise nature
  of this phenomenon remains unexplained.

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Jacque Benvenistes Studies

• That water transfers specific molecular signals
  is difficult to accept. However, this may in fact
  mimic the basic role of water dipoles associated
  with all biological molecules at a 15,000 to 1
  ratio.
• Once coherently organized like a laser by
  interaction with molecule charges, water would
  transmit oscillating electromagnetic fields (or
  any oscillating field) which may be the driving
  force of molecule-to-molecule signaling.

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Jacque Benvenistes Studies

• Digital Biology
• Biochemical reactions based on resonance
  propagation between molecules vibrating at the
  same frequency (lt 20 Hz) creating a cascade of
  electromagnetic impulses traveling at the speed
  of light

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Jacque Benvenistes Studies

• Digital Biology 1991 to 2004 (digibio.com)
• Could record molecular activity on multimedia
  computer and replay it to a biological system
  with results similar to giving the physical
  substance itself
• Basophil and neutrophil activation, skin testing,
  oxygen activity, coagulation FASEB 1995, 1996,
  1999
• Could send as email attachment and alter coronary
  blood flow in an isolated perfused guinea pig
  heart
• Identical to effects produced on the heart by
  the actual substances themselves

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Coagulation Studies
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Benveniste Summary

• Water (not ethanol, DMSO) required for signal
  transmission
• Agitation important
• Heating or freezing/thawing suppressed activity
• Dilute solutions were ALL suppressed at 70-80
  degrees C
• Whole molecules reacted to heat acc. to indiv.
  Sensitivity
• suggests a common mechanism operating at high
  dilution, independent of thestarting molecule.

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Electromagnetic Radiation
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Music
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Words
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Photograph
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Samuel Hahnemann, Physician and Chemist
Developer of Homeopathy1755-1843
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Homeopathy in Epidemics Mortality
Disease N each Convl HP tx
Typhus 1813 Germany 180 30 lt2
Cholera 1830-34 Europe 2000 56 10
Yellow Fever 1850 U.S. 5,000 44 5
Diphtheria 1879 U.S. 600/400 17 6
Influenza 1918 U.S. (Ohio) 25,000 28 1
From The Logic of Figures, T.L. Bradford, M.D.,
1900 and other sources
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Homeopathy Is

• A 200 year old system of medicine widely used in
  England, Germany, France and India today
• Scientific medicine
• 200 years clinical observations in humans
• Based on drug trials (provings) and clinical
  results
• Pioneered use of placebo controls (1880s) and
  single blinding (1890s)
• Standardized testing procedures

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Homeopathy Is

• Widely used in England, Germany, France and India
  today
• Based on symptoms, not diagnosis
• Holistic
• Treats physical, mental and emotional states

• Energy-based (Vitalistic)
• Vital Force Qi, Innate Intelligence

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Homeopathy Is

• A complete, separate system of medicine
• Language
• Preparation of medicines
• Principles for prescribing
• Understanding of health, disease, and healing

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Homeopathy Is Not

• A long word for herbal, natural, alternative,
  complementary, or holistic medicine!

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Homeopathy in the United States

• 1825 1st homeopathic physician Gram
• 1835 1st school of HP Allentown, PA
• 1844 1st national medical society AIH
• 1846 1st U.S.- published veterinary HP book
• 1860 Humphreys Manual of Veterinary
  Specific Homeopathy published
• Used by zoos, Ringling Bros, U.S. Cavalry till
  1920s
• 1865 Life Insurance companies in N.Y., London
  reduced rates to patients of HP lower mortality
  1869 AIH admitted female physicians
• 1870 Washington HP Medical Society opened
  membership w/o regard to race

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Homeopathy in the United States

• 1870 Handbook of Therapeutics 1st ed.
• By Sidney Lactated Ringer, London
• The best treatise on therapeutics we possess
  13 U.S. editions
• used HP rx Ipecac, camphor, aconite
• 1873 - gt 1000 U.S. druggists buying HP remedies
  Domestic kits many used by women for families
  and townspeople when no M.D.
• 1892 110 hospitals, 62 orphan/elderly asylums,
  30 nursing homes, 16 insane asylums
• 1910 22 HP medical schools 1 in 4-5 MDs use HP
• WWI U.S. Army 1,862 HP physicians as
  commissioned officers, and gt 1,500 nurses in U.S.
  military hospitals overseas and at home

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Prominent People who used HP

• John D. Rockefeller
• William Seward
• Pres. James Garfield
• Nathaniel Hawthorne
• Louisa May Alcott

• Samuel B. Morse
• Henry Wadsworth Longfellow
• Harriet Beecher Stowe

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Frozen Jaw after trauma

• 1 ½ yr F Golden Retriever
• 3/99 Lacerated tonsil while chewing stick.
• Tx Amoxi.
• 4/99 Fibrosis jaw opens lt 3 inches
• Anesthesia jaw forced open. Prednisone (8mos)

• 12/99 8 mos treatment jaw opens ½ inch. No
  pain or swelling in or around mouth.
• Began homeopathic treatment.
• Rads normal.
• Blood chem. normal/WBC 17,000
  (neutr)

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Frozen Jaw after trauma

• Minimal response to 2 different remedies given
  between Dec 99 and Jan 21 00 (single dose)
• 3rd remedy (3 single doses 2 wks, 10 wks apart)
• After 3 mos, back in field trials (neck retrieve)
• After 6 mos, whole body retrieve
• Jr. hunter certificate
• 1st place in conformation.

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Equine Chronic Lameness

• Horse, 6 month chronic RF lameness, no response
  to abx, NSAIDs, poultices.
• Given 1 dose of Silicea
• Became extremely lame abscess opened
• Splinter of painted wood from tack trunk
• Sound afterwards

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Rejecting Puppies

• 7 yr female Beagle mix
• 3 previous litters of puppies
• Each litter progressively worse mothering
• Allowed nursing not aggressive
• Would walk away if pups crawled on her
• 4th litter refused to nurse milk started drying
  up. Taken to clinic (day 3-4 postpartum)
• Tx Sepia 30C
• Within 30 minutes started licking, nursing,
  mothering pups. Good mother from then on.

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Stillbirths in Pigs

• Herd Problem 130 sows, 20 stillbirths
• Caulophyllum 30C PO 2/wk for ? 3 wks before
  farrowing
• Herd treatment Stillbirths Previous 20
  6 mos. Caulophyllum 2.6 2 mos.
  untreated 14.9 2 mos. Caulophyllum 1.9
• No. of stillbirths p0.018
• C. E. I. Day, Vet Record March 3, 1984

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Rediscovery Law of Similars

• Why is quinine effective against malaria?
• Hahnemann took Cinchona bark extract (source of
  quinine used for treating malaria)
• It produced symptoms similar to those of malaria
• weakness, bone pain, intermittent fever
• Symptoms went away when stopped administration
• Repeatable over many trials/many people
• Synthetic methloquine has similar effects (PDR)

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I. Law of Similars Like Cures Like

• A medicine which produces certain symptoms in a
  healthy person can cure a sick person having
  similar symptoms.
• Homeopathy
• Homeo similar pathos disease, suffering

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Symptoms

• Changes from healthy state
• Mental/emotional states cravings
• Physical functions
• Sensations
• Location Time/Season
• Character
• Cause
• Modality better/worse
• Strange, rare, or peculiar

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Symptoms of Disease Animal History Intake

• Diarrhea Yellow liquid at 7 am, or
  brown liquid stools w/ gas in pm?
• Thirst and appetite Small amts frequently
  or large amts infrequently?
• Mentals Isolates/seeks company?
• Preferences Sunny spot or near a/c vent?
  Warm or cold water?
• Modalities What makes it better/worse?

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Match patients symptoms with most similar remedy
?
?
?
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II. Law of Provings

• Conventional Test in animals and then give to
  sick patient
• HP Only by giving a single remedy at a time to a
  healthy person and observing its effects
  (symptoms) is the action of the remedy known.

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Homeopathic Provings

• Remedies still studied using experimentation and
  observation in humans
• Controlled experiment proving
• Remedy or placebo to (blinded) healthy subjects
• All symptoms recorded
• Common and uncommon symptoms IDd
• Compiled into Materia Medica
• Graded by clinical reliability

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Clinical Studies of Provings

• 2 blinded, placebo-controlled studies involving
  giving a total of 3 different HP remedies to
  healthy people and evaluating symptoms
• 1) 2004 n21 2 rx, 1 placebo more symptoms with
  remedies than placebo Forsch Komplem Klass Natur
  11(5) 274-80
• 2) 2004 n11 1 rx, 1 placebo more symptoms
  (plt0.02) with rx than placebo Homeopathy 93(4)
  179-85

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Symptoms

• Medicinal symptoms (provings)
• Resulting from administered medicine (remedy)
• Symptoms of disease
• What patient experiences in unhealthy state

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Medicinal Symptoms or Side Effects?

• Conventional
• Single drug can affect many organ systems

Side effect Adverse reaction
Main effect Secondary effect
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Viagra

• Originally a blood pressure medication
  (hypertension)
• Marketable side effect now the main effect
• Vet med treatment for pulmonary hypertension in
  dogs

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Medicinal Symptoms or Side Effects?

• Ritalin
• Mind Nervousness, insomnia, drowsiness,
  dizziness, transient depression
• Head Headache, scalp hair loss
• Heart Arrhythmias, tachycardia, pulse, BP
• Stomach Nausea, anorexia
• Skin Rash, urticaria, exfoliative dermatitis
• Extremities Joint pain
• Generals Wt. loss.
• Worse Afternoon and evening

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Medicinal Symptoms or Side Effects?

• Homeopathy
• Single remedy can affect many organ systems

Urinary
Eyes
Effects or Symptoms
Resp.
Skin
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III. Law of the Single Remedy

• Every medicine can create symptoms.
• Multiple medicines createconfusion!
• Classical homeopathy one remedy at a time.

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Combination Remedies

• Combos effective for many conditions
• Improvement may stall/be temporary
• No provings of combinations
• Change symptom picture?

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Homeopathic Remedies
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Homeopathic Remedies

• Included in Food, Drug and Cosmetic Act of 1938
• Licensed homeopathic pharmacies
• Homeopathic Pharmacopoeia of the United States
  (HPUS)
• Over 2,000 remedies proven

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Homeopathic Remedies

• Plant, animal, or mineral derived
• Rhus tox, Sepia, Silicea
• Poisons, venom, etc most powerful medicinal
  effects
• Unique method gives unique properties
• Tincture
• serial dilution/succussion
• spray onto milk sugar pill base

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Serial dilution
1 in 10 1 in 10 (X) (X)
1 in 100 1 in 100 (C) (C)
1 in 1001000 1 in 1001000 (M)
(M)
1
2
Extract in ethanol and water
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Serial dilution

• Letter (Roman Numeral) X, C, M
• size of dilution step
• Number 1, 3, 6, 10, 30, 200, etc
• number of dilutions in the series
• Potency 6X, 6C, 30C, 200C, 1M, etc

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Serial dilution

• X 10 1 in 10 dilution 10-1
• C 100 1 in 100 dilution 10-2
• 6X 6 1 in 10 dilutions 10-6
• 6C 6 1 in 100 dilutions 10-12
• Penicillin 1 in 100,000,000 BMJ 1943(ii)654
• Acetylcholine 1mg/2,000,000 L
• Science, 72 (1930) 526

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Serial dilution

• 12C 12 1 in 100 dilutions 10-24
• 30C 30 1 in 100 dilutions 10-60
• 200C 200 1 in 100 dilutions 10-400
• Avogadros number 1023 (6.0253 x 1023)

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Serial dilution and Succussion
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For each dilution step, there is a potentizing
(succussion) step.

• 12C 12 potentizing steps
• 30C 30 potentizing steps
• 200C 200 potentizing steps
• Done by hand or by machine

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NMR Studies

• Nux vomica
• 30C, 200C, 1000C (10-2000)
• Ethanol 90 30C 30C unagitated
• Differences in T1 relaxation times
• (plt0.001 3 replicates)
• Br. HP J (2000) 8973-77

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Research in Ultra-High Potencies

• Dielectric index of water
• altered by adding NaCl 27C Gay, 1951, 1952
• Caltech study (2000)
• H2O molecules form stable clusters unique
  conformation when add any substance

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Ultrahigh dilutions/ Microdoses

• 61X (10-61) Mercuric Chloride Solutions
• --Increased rate of starch hydrolysis (500
  trials) Pharm. Journal, Sept 11, 1954
• 12X-200M (10-12- 10-40,000) Sulphur Solutions
• --Affected wt, dimensions, mineral content of
• onion plants
• 1400X (10-1400) NaCl in dH2O (two 6 mo. trials)
• -- Given daily to guinea pigs affected
  appetite, wt, coat, decreased birth wts
  higher death rate. J Am Inst Hom,
  18(1925), 433-44 790-792
• Arndt-Schultz Law Tiny concentrations
  stimulate high concentrations kill.

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The Arndt-Schultz Law
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Benveniste Basophil Degranulation After Exposure
to Anti-Ig E (log dilutions) Nature, 1988
333(6176) 816-8
110 series
1100 series
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How does homeopathy work?
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Then a miracle occurs
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The Remedies

• Potentization brings out the true essence of
  the substance, refining and amplifying its
  healing effects
• Hahnemann

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The Vital Force

• The potency (energetic strength) of a remedy is
  matched to the strength of patients vital force
  (vitality)
• Potency Patient
• Low 6X-200X 6C, 12C Old/weak
• Medium 30C to 200C Moderate
• High 1M, 10M Young or acute
  injury

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The Vital Force

• Energetic basis of life, health, disease
• Qi Innate Intelligence
• Responsible for immune function, growth,
  maintenance, repair
• Disease begins on energetic level

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The Vital Force

• Vital force produces symptoms
• Indication of imbalance/disturbance/damage

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Symptoms and the Vital Force

• Deeper level symptoms deeper imbalance
• Indicate health (vigor) of Vital Force
• Indicate imbalances in Vital Force
• Guides to what the Vital Force needs
• Law of Similars

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The Vital Force

• Energetically based remedies stimulate the
  Vital Force to act on energetically based disease.

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The Vital Force

• Assess response
• Patients symptoms change
• --Improvement in overall well-being
• --Improvement may be rapid, gradual, or
  accompanied by temporary stirring up of
  symptoms (aggravation)

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Aggravations

• Thompson et al, Homeopathy 2004 93(4)302-9
• Audit of remedy reactions, Bristol HP Hospital
  (n116 patients)
• --24 experienced an aggravation
• --27 experienced new symptoms
• --18 had a return of old symptoms
• -- appeared to have better outcome

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Clinical Research

• Positive and negative studies
• Recent papers Positive results for
• Fibromyalgia (n53) Bell et al Fibromyalgia
• Mild viral infections (n485) 67.9 v 47.9
  asymptomatic (Rabe et al Int J ClinPract 2004
  58(9)827-32
• Septic and intubated patients in critical care 2
  RCT Wien  Med Wochenschr. 2005 Nov155(21-22)491-
  7.
• Chronic disease (n3,981) 2 yr study(allergic
  rhinitis, migraine, atopic dermatitis 8.8 yrs
  ave duration)
• Patient assessments of disease severity
  significantly decreased from 6.2 in adults (6.1
  in children) at baseline to 2.2 (2.2 in children)
  after 24 months. Witt CM, Ludtke R, et al, BMC
  Public Health, 2005 5 115.

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Clinical Research

• Meta-analysis 107 controlled trials
• 81 showed positive results
• 22 trials with best methodology
• 15 had positive results
• 7 no positive result could be detected
• Kleijnen et al BMJ, Feb 9, 1991

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Summary

• Homeopathy is a system of medicine that uses
  energetically potentized medicines to stimulate a
  healing response by the Vital Force.
• The action of a medicine is known by giving it to
  healthy individuals and recording its effects
  (proving).
• A single remedy is matched to the patients
  symptom picture on the basis of the provings.
• The response is evaluated by the changes in the
  symptoms and the patients overall well-being.

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The highest ideal of cure is rapid, gentle, and
permanent restoration of the health, or the
removal and annihilation of the disease in its
whole extent, in the shortest, most reliable, and
most harmless way, using easily understood
principles. -- Samuel Hahnemann