?????proteomics (protein genomics)

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?????proteomics (protein genomics)

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Title: ?????proteomics (protein genomics)

1
??? ??????

????????
??????
?????proteomics (protein genomics)
????? structural biology
????? bioinformatics
???? biochip

2
?????????

??????????
(International Human Genome Consortium)
??????? NIH ( National Institute of Health)
???????
??Sanger?? (?????????)
?????????????????
????????????????
(National Human Genome Research Institute)

3
2000?????????????
???? ?????????
????? 5??????? ???????
?????? 99?? 90 (43???)
?????? 26,383 23,147
?????? ????? ??????? ?? ?????
SNPs?? ?????? ??????
?? 9?? 14?
????? Craig Venter Francis Collins
4
??????
5
2003????????????
?? ?? ?? ????
???? 2 to 5cM (600 1,500??) 1-cM (3,000 ??) 1994.9
???? 30,000 STSs 52,000 STSs 1998.10
DNA?? 95 gene finished to 99.99 2003.4
?? lt 0.25 base lt0.09 base 2002.11
DNA?? 100,000 SNPs 3.7 million SNPs 2003.1
?? Full-length cDNAs 15,000 cDNAs 2003.3
6
????????????
7
???????

???????30.8?????
????(euchromatic)??28.8?????
???????341??
???????33 ??( 1.98?????)
???????308 ??(2800?????)
?????
20,000-25,000 (?22,287 ???)
34,214 ????
????3400?????,? 1.2
????2100?????,? 0.7
19,599 ???????
2,188 DNA ????????????

8
?????????
(???, 2006)
9
????????????
??????????????????????? ????????????????(gap)
10
????????????????
??HGP??? ??????????
11
?????????
?? ?????
?????? Amoeba dubia 670,000
?????? Amoeba proteus 270,000
??????Ophioglossum petiolatum 160,000
???? Protopterus aethiopicus 139,000
??? Fritillaria assyriaca 124,900
???? Lilium longiflorum 90,000
????? Amphiuma means 84,000
?? Necturus maculosus 81,300
???? Pinus resinosa 68,000
???? Lilium formosanum 36,000
????Coscinodiscus 25,000
?? Triturus cristatus 20,600
12
?????????
?? ?????
?? Allium cepa 18,000
???? Schistocerca gregaria 9,300
??? Paramecium caudatum 8600
???? Bufo bufo 6900
??? Scyliorhinus ???? 6000
?? Orycteropus afer 5763
?? Peromyscus eremiticus 5295
???Tarsius syrichta 5152
??Cercopithecus cephus 5142
??Cercopithecus nigroviridis 5117
??Zea mays 5000
??Homo spaiens 3080
????http//www.cbs.dtu.dk/databases/DOGS/index.ph
p
13
???????????
1995 ???? 1.83 Mb, 1740 ?? ??? 0.58 Mb,
517 ?? 1996 ??? 12 Mb, 6000 ?? ??? 1.7
Mb, 1738 ?? 1997 ???? 4.6 Mb, 4289 ?? 2001 ?? 97
Mb, 20262??(?? 1998) 2002 ?? 365 Mb, 30000??
?? 2500 Mb, 25000??(?? 2002) 2003 ?? 430 Mb,
50000?? 2003 ?? 128 Mb, 13600??(?? 2000) 2003 ??
3000 Mb, 25000??(?? 2000)
14
??????